Actively Recruiting
MRI Based Biomarkers in Pediatric Autoimmune Liver Disease
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2024-12-12
115
Participants Needed
1
Research Sites
523 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Autoimmune liver diseases (AILD), which include Primary Sclerosing Cholangitis (PSC) and Autoimmune Hepatitis (AIH) are a common etiological factors for chronic liver disease among adolescents. In all these conditions, autoimmune lymphocyte responses are thought to orchestrate inflammatory injury against hepatocytes (primarily in AIH) or cholangiocytes (in PSC). In this proposal we aim to evaluate the Magnetic Resonance Imaging (MRI) modalities; MR cholangiopancreatography (MRCP) and MR elastography (MREL), as non-invasive biomarkers to assess two primary pathophysiological processes of AILD: bile duct damage and liver fibrosis. In this cross-sectional study MRI based findings of bile duct injury and liver fibrosis will be correlated with both liver histology and circulating biomarkers of these disease processes.
CONDITIONS
Official Title
MRI Based Biomarkers in Pediatric Autoimmune Liver Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 6 to 23 years old
- Established or suspected clinical diagnosis of Autoimmune Hepatitis or Primary Sclerosing Cholangitis
You will not qualify if you...
- History of liver transplantation
- Chronic Hepatitis B or untreated Hepatitis C virus infection
- Pregnancy
- Absolute contraindication for MRI such as pacemaker, metallic implants, or claustrophobia
- Diagnosis of cystic fibrosis or biliary atresia
- Diagnosis of cardiac hepatopathy
- Diagnosis of Wilson's disease, Alpha-1 Antitrypsin deficiency, or Glycogen storage disease
- Skin conditions that could worsen with MR elastography, such as Epidermolysis bullosa
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cincinnati Childrens Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
Research Team
A
Alexander Miethke, MD
CONTACT
C
Cyd Castro Rojas, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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