Actively Recruiting
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
Led by UNC Lineberger Comprehensive Cancer Center · Updated on 2025-09-19
15
Participants Needed
1
Research Sites
353 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Brain metastases are a source of much morbidity and mortality in adults with primary solid malignant tumors. With improvements in systemic therapy that prolong survival but have limited central nervous system penetration, patients with brain metastases are at increasing risk of developing and experiencing long-term side effects from treatment of brain metastases. The overarching goal of this study is to better understand the determinants of RT-associated changes in white and gray matter function and associated neurocognitive decline.
CONDITIONS
Official Title
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologic diagnosis of cancer
- Newly diagnosed brain metastasis being treated with stereotactic radiosurgery (SRS); any extent of cranial disease allowed
- Subsequent SRS courses during study allowed if clinically needed
- Patients may have had craniotomy and metastasis resection if at least one other intact metastasis is planned for SRS
- Receiving or previously received systemic therapy allowed
- Life expectancy of at least 1 year
- Age 18 years or older
- Ability to read, understand, and follow instructions in English
- Ability to provide informed consent
You will not qualify if you...
- Previous radiation to the brain or head
- Previous malignancy (other than non-melanomatous skin cancer or cervical carcinoma in situ) unless disease-free for at least 3 years
- Previous severe head or brain injury
- History of neurological disorders such as epilepsy, Parkinson's disease, Alzheimer's disease, or dementia
- Prisoners
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of North Carolina at Chapel Hill, Department of Radiation Oncology
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
Research Team
B
Becky Green
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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