Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT02988921

MRI and CT Simulation in the Evaluation of Tumor Response and Target Volume Definition for Esophageal or Esophagogastric Cancer Patients Undergoing Chemoradiotherapy

Led by Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Updated on 2023-11-24

300

Participants Needed

1

Research Sites

530 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Magnetic resonance imaging (MRI) with functional features of diffusion weighted imaging (DWI) are advancing imaging technologies that have potential to overcome limitations of conventional staging methods, radiation treatment planning and the assessment of tumor response in esophageal or esophagogastric cancer. This study aimed to explore the value of MRI for the prediction of tumor response to chemoradiotherapy and accurate target volume delineation as compared to CT simulation for patients with unresectable or potentially resectable esophageal or esophagogastric cancer undergoing chemoradiotherapy. The average CT texture features are also extracted before and during treatment to establish a model to predict the prognosis or side effects (e.g. radiation pneumonitis or esophagitis) of patients.

CONDITIONS

Official Title

MRI and CT Simulation in the Evaluation of Tumor Response and Target Volume Definition for Esophageal or Esophagogastric Cancer Patients Undergoing Chemoradiotherapy

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Histologically confirmed squamous cell carcinoma or adenocarcinoma of the esophageal or esophagogastric junction
  • Unresectable or potentially resectable tumor (cT3-4N0-1M0-M1a) based on standard staging by EUS and CT
  • Age over 18 years
  • No distant metastasis except supraclavicular lymph nodes
  • No prior thoracic radiation or chemotherapy
  • Normal organ and marrow function: leukocytes ≥ 3,500 G/L; platelets ≥ 100,000/mm3; hemoglobin ≥ 10g/L; bilirubin within normal limits; AST/ALT ≤ 1.5 times upper limit; creatinine within normal limits
  • Informed consent provided
Not Eligible

You will not qualify if you...

  • Contraindication for MRI scanning
  • History of other cancers except cervical carcinoma in situ and non-malignant melanoma skin cancer
  • Pregnant or breastfeeding females
  • Contraindications for radiotherapy or chemotherapy

AI-Screening

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Trial Site Locations

Total: 1 location

1

Department of Radiation Oncology, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)

Beijing, China, 100021

Actively Recruiting

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Research Team

X

Xin Wang, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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