Actively Recruiting
MRI Guided Closed-loop TMS-EEG
Led by Sunnybrook Health Sciences Centre · Updated on 2024-08-13
160
Participants Needed
1
Research Sites
203 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this interventional study is to develop an individualized approach using transcranial magnetic stimulation (TMS) in a high-precision manner. This approach will use TMS to modulate brain activity at multiple locations simultaneously. Functional magnetic resonance imaging (fMRI) and electroencephalograph (EEG) will record the responses and guide the stimulation. Specifically, the placement and orientation of TMS coils will be tailored to stimulate the targeted functional brain areas informed by fMRI. To maximize the interventional effect, stimulation pulses will be delivered based on EEG oscillations.
CONDITIONS
Official Title
MRI Guided Closed-loop TMS-EEG
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For healthy participants: aged 18 to 65 years
- Healthy with no history of neurological impairment
- Normal or corrected-to-normal vision
- For participants with amnestic mild cognitive impairment (aMCI): aged 50 to 80 years
- Cognitive symptoms including a self- or informant-reported complaint, preserved independence, and no dementia
- Objective cognitive impairment shown by Mini-Mental State Exam score 24-27, Montreal Cognitive Assessment score 18-26, or Clinical Dementia Rating Scale score of 0.5
- Normal or corrected-to-normal vision
You will not qualify if you...
- Women who are pregnant or breastfeeding
- History of seizures (except childhood febrile seizures), epilepsy in self or first-degree relatives, stroke, brain tumor, brain surgery, head injury, or known brain lesions
- Presence of metal in the eye or skull area, brain stimulators, surgical metal, clips in the brain, cochlear implants, or metal fragments in the eye
- Non-MRI compatible metal implants such as cardiac pacemakers or aneurysm clips
- Claustrophobia or inability to lie comfortably supine for up to 1 hour
- Participation in any other non-invasive brain stimulation study within the last two weeks
- Abnormal neurological examination findings
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
Research Team
F
Fa-Hsuan Lin, PhD
CONTACT
H
Hsin-Ju Lee, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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