Actively Recruiting
MRI in High-Grade Glioma Patients Undergoing Chemoradiation
Led by Wake Forest University Health Sciences · Updated on 2026-03-23
16
Participants Needed
1
Research Sites
221 weeks
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to see if investigators can predict how brain functioning changes after radiation treatment based on PET scans and blood tests. Most participants experience at least mild decreases in their memory or attention after radiation therapy. Investigators hope that PET scans, lumbar puncture, and blood tests might help investigators predict who might have larger changes in their brain function after radiation.
CONDITIONS
Official Title
MRI in High-Grade Glioma Patients Undergoing Chemoradiation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically confirmed diagnosis of high-grade glioma (grade III or IV) or WHO grade II glioma, IDH wildtype (molecular glioblastoma multiforme [GBM]).
- 18 years of age or older.
- ECOG performance status of 0 to 3.
- Anticipated to receive 6 weeks of chemoradiation.
You will not qualify if you...
- Does not speak or read English.
- Unable to participate in cognitive testing due to aphasia or other severe cognitive impairment as determined by the PI, or Dr. Cummings or her designee.
- Unable to give informed consent.
- Past medical history of any kind of dementia or diagnosed with mild cognitive impairment prior to diagnosis with their brain tumor.
- Unable to safely fast for 8 hours prior to bloodwork or 6 hours prior to PET scan.
- Currently taking cognition-enhancing medications including Donepezil, Memantine, Armodafinil, or Methylphenidate.
- Pregnant or nursing mothers.
- Patients taking blood thinners are excluded from the optional lumbar puncture only but may participate in the main study if they meet other criteria.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
Research Team
S
Study Coordinator
CONTACT
S
Study Nurse
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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