Actively Recruiting
MRI Screening of Placenta Adhesion Abnormalities
Led by Central Hospital, Nancy, France · Updated on 2025-02-13
71
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Placenta Adhesion Abnormalities (PAA) are the consequence of an excessive invasion of the placenta within the myometrium. PAA are related to severe maternal pregnancy outcomes, especially in case of incidental discovery during delivery that increase the risk of intraoperative massive bleeding, hysterectomy and even maternal death. Ultrasound is the standard modality for diagnosing PAA, but Magnetic Resonance Imaging (MRI) has been increasingly performed in the case of inconclusive sonographic findings. However, standard morphological MRI sequences appear as insufficient to improve the sensitivity and specificity values for detecting PAA, while quantitative MRI may be more efficient. The main objective of this study is to characterize the diagnostic performance of quantitative MRI parameters (mainly Apparent Diffusion Coefficient, T2 and T2\*) reflecting placental perfusion and/or oxygenation at high field, without injection of gadolinium-based agent, for the detection of PAA in women with ongoing pregnancy between 30 and 38 weeks of gestation with risk factors for PPA.
CONDITIONS
Official Title
MRI Screening of Placenta Adhesion Abnormalities
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant participant between 30 and 38 weeks of gestation
- Age 18 years or older
- Participant who completed the preliminary medical examination
- Participant who has received full information about the research and has signed informed consent
- Participant planning to give birth at CHRU of Nancy
- Participant presenting risk factors for PAA such as low-lying or covering placenta or placenta in front of the uterine scar
You will not qualify if you...
- Multiple pregnancy
- Participant with any contraindication or restriction to MRI as outlined in the study protocol
- Participant unable to understand or follow the study procedures
- Person referred to in Articles L. 1121-6 to L. 1121-8, L1122-2 and L. 1122-1-2 of the Public Health Code
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Centre Hospitalier Régional Universitaire de Nancy
Vandœuvre-lès-Nancy, France, 54500
Actively Recruiting
Research Team
C
Charline BERTHOLDT, MI
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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