Actively Recruiting
MRI Study of Subjects with ASD, Their Relatives and TD
Led by Institut National de la Santé Et de la Recherche Médicale, France · Updated on 2025-03-13
1000
Participants Needed
2
Research Sites
913 weeks
Total Duration
On this page
Sponsors
I
Institut National de la Santé Et de la Recherche Médicale, France
Lead Sponsor
A
APHP
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project is structured around a central study called "Study of genetic factors involved in autism and related conditions ("Genes and Autism" study, sponsor: INSERM). This study explores clinical and genetic aspects of ASD (autism spectrum disorders) and is complemented with several ancillary studies (such as this one) which will use the data of the main study and will allow an extensive review of phenotypes associated with ASD. In this ancillary study, we will go on the acquisition of anatomical, diffusion and functional MRI in subjects with ASD, relatives and controls. Our group has already performed several neuroanatomical studies of ASD. IWe recruited since 2010 more than 600 subjects (proponents, relatives and controls) to better understand the implication of brain abnormalities in ASD. This study involves specialized teams in neuroiamging based at INSERM, NeuroSpin (CEA), Robert Debré Hospital (APHP) and Pasteur Institute Our main objective is to identify structural, connectivity and functional peculiarities in subjects with ASD Secondary objectives include: * the identification of familial heritability patterns of ASD * correlate data obtained in brain imaging with genetic data * assess specificity and statistical reproducibility of the obtained results
CONDITIONS
Official Title
MRI Study of Subjects with ASD, Their Relatives and TD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
- Having at least 24 months of age
- Being affiliated with the French health insurance
- Having signed the informed consent (by the participant or legal guardian if under 18 or under legal custody)
- For patients: having an ASD diagnosis fulfilling DSM-5 criteria confirmed by a clinical expert using structured instruments (ADI-R, ADOS-2)
You will not qualify if you...
- Severe mental retardation (IQ <35 or developmental age <18 months)
- Medical conditions (psychiatric or physical) not compatible with inclusion
- MRI contraindications
- Current pregnancy or breastfeeding
- Not willing to be informed of brain abnormalities diagnosed by MRI
- For relatives: discovery of non-filiation during genetic analysis
- For controls: neurological history (except mental retardation)
- For controls: personal history of schizophrenia, addiction, bipolar disorder, recurrent depression (>2 episodes), severe uncontrolled anxiety, epilepsy episodes, significant inflammatory disease or immunosuppressive medication
- For patients: ASD diagnosis not confirmed after inclusion
- Discovery of MRI contraindication during exam (e.g., claustrophobia)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
NeuroSpin neuroimaging platforme
Gif-sur-Yvette, France, 91191
Not Yet Recruiting
2
APHP, Hôpital Robert Debré
Paris, France, 75019
Actively Recruiting
Research Team
R
Richard Delorme, M.D, Ph.D
CONTACT
J
Josselin Houenou, M.D, Ph.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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