Actively Recruiting
MRI in Transcatheter Aortic Valve Replacement Patients
Led by University Hospitals Cleveland Medical Center · Updated on 2025-12-17
90
Participants Needed
1
Research Sites
162 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The hypothesis is that SEV result in superior valvular hemodynamics (more pronounced during exercise) and exercise capacity relative to BEV. Furthermore, the hypothesis is that stress CMR will be able to demonstrate differences in these hemodynamic parameters. CMR will also provide refined assessment of paravalvular leak and its impact on ventricular function and on clinical outcomes.
CONDITIONS
Official Title
MRI in Transcatheter Aortic Valve Replacement Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aortic valve stenosis with clinical indication for valve replacement decided by a dedicated heart team
- Planned transfemoral transcatheter aortic valve replacement (TAVR)
- 18 years of age or older
- Able to give informed consent
You will not qualify if you...
- Presence of permanent pacemakers or implantable defibrillators
- Non-MRI safe implants
- Severe claustrophobia
- Inability or contraindication to perform exercise bike stress test
- Arrhythmia preventing adequate cardiac gating, including atrial fibrillation
- Left ventricular systolic function less than 40%
- History of surgical aortic valve replacement or valve-in-valve TAVR procedures
- Significant untreated coronary artery disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
Research Team
L
Luis Dallan, MD
CONTACT
L
LaStasha Cowan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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