Actively Recruiting
MRS Measurement of Glutamate and GABA Metabolism in Brain
Led by National Institute of Mental Health (NIMH) · Updated on 2026-04-20
200
Participants Needed
1
Research Sites
1226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of \[13\]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA).
CONDITIONS
Official Title
MRS Measurement of Glutamate and GABA Metabolism in Brain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 65 years
- Able to give written informed consent
- Healthy based on medical history and physical exam
- Enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
You will not qualify if you...
- Any current Axis 1 psychiatric diagnosis
- Clinically significant laboratory abnormalities
- Positive HIV test
- Presence of metallic foreign bodies or severe claustrophobia preventing MRI
- History of neurological illness or injury affecting study data
- Use of psychotropic medications within the last 8 weeks
- Serious medical illness including diabetes
- Inability to lie flat for about two and a half hours
- Pregnant or breastfeeding
- Current substance use disorder
- NIMH employees, staff, and their immediate family members
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
C
Christopher S Johnson
CONTACT
L
Li An, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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