Actively Recruiting
MRSI Evaluation for Minor Stroke With Large Vessel Occlusion
Led by Shanghai 6th People's Hospital · Updated on 2024-10-16
75
Participants Needed
1
Research Sites
176 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke (LVO-MIS) evolution using magnetic resonance spectroscopic imaging evaluation. The main questions it aims to answer are: 1. Neurometabolic predictors of early neurological deterioration and functional outcome; 2. Temporal and spatial dynamic changes of the neurometabolites from the acute stage (within 24 hours), through the subacute stage (5-7 days), to the chronic stage (90 days); 3. Temporal and spatial dynamic changes of the neurotransmitters GABA, glutamate, and glutamine from the acute stage to the chronic stage; 4. Brain regions exhibiting changes in whole-brain metabolic network connectivity.
CONDITIONS
Official Title
MRSI Evaluation for Minor Stroke With Large Vessel Occlusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older with symptoms of acute ischemic stroke due to occlusion in the intracranial internal carotid artery or M1 or M2 segment of the middle cerebral artery
- Mild symptoms at admission with NIH Stroke Scale score less than 6
- Baseline multimodal CT imaging performed, including non-contrast CT, CT angiography, and CT perfusion
- Time from symptom onset or last known normal to enrollment within 24 hours
- Patient or legal representative willing and able to give informed consent and comply with study procedures
You will not qualify if you...
- Pre-stroke modified Rankin Scale score of 1 or higher
- History of cerebral infarction, cerebral hemorrhage, brain tumor, or other conditions affecting brain metabolism
- Unable or unwilling to undergo magnetic resonance examination
- Severe heart, liver, or kidney problems or other serious systemic diseases
- Pregnant or breastfeeding
- Life expectancy less than 3 months
- Any condition that makes participation unsafe or unsuitable, including psychiatric, cognitive, or emotional disorders affecting ability to comply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 213000
Actively Recruiting
Research Team
L
Li Cao, phD
CONTACT
J
Jiangshan Deng, phD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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