Actively Recruiting
MSA-01 in Multiple System Atrophy
Led by Tokyo University · Updated on 2026-03-04
140
Participants Needed
12
Research Sites
111 weeks
Total Duration
On this page
Sponsors
T
Tokyo University
Lead Sponsor
N
Nobelpharma
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate whether MSA-01 slows the progression of multiple system atrophy (MSA) and to assess its safety. The primary question is: • Does MSA-01 slow the progression of motor impairment as measured by UMSARS Part 2 score? Participants will be randomly assigned to receive MSA-01 or placebo for 12 months. They will attend regular clinic visits for safety and efficacy assessments and record their medication use and any side effects in a diary.
CONDITIONS
Official Title
MSA-01 in Multiple System Atrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed as clinically established or clinically probable multiple system atrophy based on revised Movement Disorder Society criteria
- Able to walk independently or with assistive devices
- Able to attend outpatient visits at the study site
- Able to stop taking coenzyme Q10 supplements before starting study drug
You will not qualify if you...
- Having severe neurological disorders, other progressive movement disorders, or cognitive impairment
- Having severe liver disease
- Known allergy to any component of the study drug
- Pregnant, breastfeeding, or possibly pregnant women
- Previous participation in an MSA-01 clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
Nagoya University Hospital
Nagoya, Aichi-ken, Japan
Not Yet Recruiting
2
Chiba University Hospital
Chiba, Chiba, Japan
Not Yet Recruiting
3
Kyushu University Hospital
Fukuoka, Fukuoka, Japan
Not Yet Recruiting
4
Hokkaido University Hospital
Sapporo, Hokkaido, Japan
Not Yet Recruiting
5
Kagoshima University Hospital
Kagoshima, Kagoshima-ken, Japan
Not Yet Recruiting
6
Kyoto University Hospital
Kyoto, Kyoto, Japan
Not Yet Recruiting
7
Okayama University Hospital
Okayama, Okayama-ken, Japan
Not Yet Recruiting
8
NHO Higashisaitama National Hospital
Hasuda, Saitama, Japan
Not Yet Recruiting
9
Institute of Science Tokyo Hospital
Bunkyō-Ku, Tokyo, Japan
Not Yet Recruiting
10
The University of Tokyo Hospital
Bunkyō-Ku, Tokyo, Japan
Actively Recruiting
11
National Center Hospital, National Center of Neurology and Psychiatry
Kodaira, Tokyo, Japan
Not Yet Recruiting
12
Tottori University Hospital
Yonago, Tottori, Japan
Not Yet Recruiting
Research Team
J
Jun Mitsui
CONTACT
I
Ikue Wada
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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