Actively Recruiting
MSOT as Non-invasive Biomarker for Diagnosis and Monitoring of Neuromuscular Diseases
Led by Children's Hospital of Eastern Ontario · Updated on 2025-02-12
240
Participants Needed
1
Research Sites
177 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to learn if Multispectral Optoacoustic Tomographs (MSOT) works to diagnose and follow the course of neuromuscular diseases (NMDs) in children. MSOT scans will be obtained from muscle region to measure hemo/myoglobin, collagen and lipid content/signal and oxygenation in patients with neuromuscular diseases. No additional research activities -other than MSOT - will be done during this study. Existing clinical, laboratory and imaging data from standard-of-care procedures will be correlated with the MSOT data. The expected total duration of the study is approximately 36 months. Repeated measurements will be done to evaluate disease progression and the value of MSOT in NMD.
CONDITIONS
Official Title
MSOT as Non-invasive Biomarker for Diagnosis and Monitoring of Neuromuscular Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with neuromuscular disease
- Children from birth (infants born at term) to 18 years of age
- Confirmed or suspected diagnosis of a neuromuscular disease through molecular genetics, biopsy, or clinical examination
You will not qualify if you...
- Diagnosis not consistent with confirmed or suspected neuromuscular disease
- Active skin lesions such as infections or trauma
- Confirmed genetic disorders that cause skin lesions (e.g., epidermolysis bullosa)
- Medically unstable patients
- Tattoos on skin over the area to be examined
- Missing consent form
- Any condition that compromises safety or data quality as judged by the investigator
- Medication causing increased light sensitivity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHEO
Ottawa, Ontario, Canada, K1H 8L1
Actively Recruiting
Research Team
H
Hanns Lochmuller, Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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