Actively Recruiting
MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies
Led by Masonic Cancer Center, University of Minnesota · Updated on 2026-04-06
70
Participants Needed
1
Research Sites
394 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a phase II, open-label, prospective study of T cell receptor alpha/beta depletion (TCR α/β TCD) peripheral blood stem cell (PBSC) transplantation for children and adults with hematological malignancies. This is a safety/feasibility study of the investigational procedure/product.
CONDITIONS
Official Title
MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histological confirmation of hematological malignancies
- Diagnosis of acute leukemias including AML and related precursor neoplasms
- Favorable risk AML defined by specific criteria
- Acute lymphoblastic leukemia (ALL) or lymphoma
- Myelodysplasia (MDS) IPSS INT-2 or High Risk including RAEB, RAEBt, or severe pancytopenia
- Age 60 years or younger at consent
- Karnofsky performance status ≥ 70% or Lansky play score ≥ 50% for age ≤16 years
- Adequate organ function
You will not qualify if you...
- Pregnant or breastfeeding
- Active uncontrolled infection within 1 week before starting preparative therapy
- Known HIV positive or active Hepatitis B or C with detectable viral load
- Prior autologous or allogeneic transplant
- Chronic myelogenous leukemia (CML) blast crisis
- Active central nervous system malignancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Minnesota Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
M
Margaret MacMillan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
8
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