Actively Recruiting
MTOR Inhibitors in Older Adults
Led by University of Texas Southwestern Medical Center · Updated on 2026-02-02
60
Participants Needed
1
Research Sites
92 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
U
University of Maryland, Baltimore
Collaborating Sponsor
AI-Summary
What this Trial Is About
Over the past decades, healthcare systems face significant challenges to meet the needs of an aging population due to progressive debility, functional decline and chronic diseases development. While there is a growing appreciation of the potential impact of mTOR inhibitors on slowing aging processes, preventing chronic disease and prolonging healthy lifespan, a major challenge in developing clinical trials to establish the clinical efficacy of mTOR inhibitors is the absence of pharmacokinetics (PK) and pharmacodynamics (PD) data in older adults. The proposed study will provide the foundation for future clinical trials assessing the role of mTOR inhibitors on aging related indications
CONDITIONS
Official Title
MTOR Inhibitors in Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Community-dwelling adults
- Age 65 years and older
- Able to understand and follow trial procedures
You will not qualify if you...
- Creatinine clearance less than 30 mL/min
- History of chronic liver disease
- Uncontrolled hypertension with systolic blood pressure over 160 mm Hg
- Hemorrhagic central nervous system event within 1 year prior to screening
- Thrombotic event (DVT or PE) within 1 year prior to screening if not on anticoagulation
- Planned major surgical procedures
- Cardiovascular disease such as heart failure or myocardial infarction admission within 12 months
- Taking medications that affect sirolimus blood concentrations
- Participation in another investigational therapy within 1 month prior to screening
- History of dementia
- Dependence in any Katz Basic Activities of Daily Living
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
I
Irina Timofte, MD, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
6
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