Actively Recruiting
mTOR as Mediator of Insulin Sensitivity Study
Led by University of Copenhagen · Updated on 2024-05-16
10
Participants Needed
1
Research Sites
381 weeks
Total Duration
On this page
Sponsors
U
University of Copenhagen
Lead Sponsor
D
Danish Diabetes Academy
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study investigates the role of mTOR in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. This will be investigated in young healthy male subjects by administering the pharmacological mTOR inhibitor Rapamycin in a crossover blinded experimental setup known to enhance muscle insulin sensitivity following one-legged knee-extensor exercise.
CONDITIONS
Official Title
mTOR as Mediator of Insulin Sensitivity Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy men aged 22 to 35 years
- No known diseases and no family history of diabetes
- No use of medications
- Non-smokers
- Physical activity level (VO2peak) between 30-50 mL O2/min/kg
- Body mass index between 18.0 and 25.0
You will not qualify if you...
- Women
- Physical activity above 6 hours per week (running, cycling, fitness, etc.)
- Signs of metabolic, blood, liver, thyroid diseases, HIV, hepatitis, or other diseases affecting study outcome or wellbeing
- Acute illness within 2 weeks before study start
- Development of disease or need for medication after inclusion but before study start
- Disease occurring during study conclusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Copenhagen
Copenhagen, Denmark, 2100
Actively Recruiting
Research Team
J
Jørgen FP Wojtaszewski, Professor
CONTACT
M
Magnus R Larsen, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
NON_RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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