Evaluating Mucoadhesive Clobetasol and Clobetasol-Resveratrol Patches for Treating Oral Lichen Planus in Adults

What this Trial Is About

Researchers are evaluating new mucoadhesive patches containing clobetasol, alone or combined with resveratrol, to reduce symptoms and improve quality of life in adults with symptomatic Oral Lichen Planus OLP. This chronic inflammatory oral condition causes painful lesions and burning sensations, negatively affecting daily well-being. The trial aims to see if these patches can better manage pain, lesion appearance, and overall oral health compared to a standard clobetasol ointment. Participants are randomly assigned to one of three groups a patch with clobetasol propionate 0.05%, a patch with clobetasol plus resveratrol, or a clobetasol 0.05% adhesive paste. Each treatment is applied once daily for 30 days directly to the oral lesion after oral hygiene, with no food or drink for 30 minutes afterward. The patches are self-adhering and dissolve on their own. During the study, participants attend three visits at the start, day 15, and day 30 for clinical evaluations, symptom scoring, and imaging with Optical Coherence Tomography OCT to monitor tissue healing. They complete questionnaires about pain, symptoms, and oral health-related quality of life. Researchers measure changes in pain, lesion severity, quality of life, treatment compliance, and mucosal structure over the 30-day period to assess the treatments effects.

Mucoadhesive Modified-Release Formulations for the Topical Treatment of Symptomatic Oral Lichen Planus