Actively Recruiting
Mucous Fistula Refeeding Reduces the Time From Enterostomy Closure to Full Enteral Feeds ("MUC-FIRE" Trial)
Led by University of Leipzig · Updated on 2026-05-01
120
Participants Needed
17
Research Sites
493 weeks
Total Duration
On this page
Sponsors
U
University of Leipzig
Lead Sponsor
G
German Research Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective of this study is to demonstrate that mucous fistula refeeding between enterostomy creation and enterostomy closure reduces the time to full enteral feeds after enterostomy closure compared to standard of care.
CONDITIONS
Official Title
Mucous Fistula Refeeding Reduces the Time From Enterostomy Closure to Full Enteral Feeds ("MUC-FIRE" Trial)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants younger than 366 days
- Presence of ileostomy or jejunostomy
- Double loop enterostomies and split enterostomies with mucous fistula
- Signed informed consent from parents or legal guardians and willingness to comply with study procedures
You will not qualify if you...
- Resection of the ileocecal valve
- Presence of colostomy
- Small bowel atresia
- More than two ostomies (enterostomy plus mucous fistula)
- Known chromosomal abnormalities at the time of randomization
- Hirschsprung's disease
- Participation in another drug-intervention study
- Intestinal perforation caused by a hemodynamic heart defect
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
Universitätsklinik für Kinder- und Jugendchirurgie
Graz, Austria, 8036
Actively Recruiting
2
Universitätsklinik für Kinder- und Jugendheilkunde
Vienna, Austria, 1090
Actively Recruiting
3
Universitätsklinik für Kinder- und Jugendmedizin Tübingen
Tübingen, Baden-Wurttemberg, Germany, 72076
Actively Recruiting
4
Städtisches Klinikum München GmbH/ Klinikum Schwabing
München, Bavaria, Germany, 80804
Actively Recruiting
5
Zentrum der Chirurgie, Klinik für Kinderchirurgie
Frankfurt am Main, Hesse, Germany, 60590
Terminated
6
Auf der Bult, Kinder- und Jugendkrankenhaus, Kinderchirurgie und Kinderurologie
Hanover, Lower Saxony, Germany, 30173
Actively Recruiting
7
Hannover Medical School, Clinic for Pediatric Surgery
Hanover, Lower Saxony, Germany, 30625
Actively Recruiting
8
Marien Hospital Witten, Ruhr-University Bochum, Department of Pediatric Surgery
Witten, North Rhine-Westphalia, Germany, 58452
Actively Recruiting
9
Universitätsmedizin Mainz, Klinik und Poliklinik für Kinderchirurgie
Mainz, Rhineland-Palatinate, Germany, 55131
Withdrawn
10
Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Kinderchirurgie
Dresden, Saxony, Germany, 01304
Terminated
11
University of Leipzig
Leipzig, Saxony, Germany, 04103
Actively Recruiting
12
University Hospital Augsburg, Clinic for Pediatric Surgery
Augsburg, Germany, 86156
Actively Recruiting
13
Hamburg [University Hospital Hamburg Eppendorf/UKE & Altonaer Kinderkrankenhaus/AKK]
Hamburg, Germany, 20246
Not Yet Recruiting
14
University Hospital Marburg, Clinic for Pediatric Surgery
Marburg, Germany, 35043
Actively Recruiting
15
Munich Clinic Harlaching
München, Germany, 81545
Actively Recruiting
16
Amsterdam University Medical Centers
Amsterdam, Netherlands, 1000 GG
Actively Recruiting
17
Erasmus University Medical Center Rotterdam
Rotterdam, Netherlands, 3015 CE
Actively Recruiting
Research Team
M
Martin Lacher, Prof. Dr. med.
CONTACT
O
Omid Madadi-Sanjani, PD Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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