Actively Recruiting
Mueller Polarimetric Colposcopy for High-performance Detection of Cervical Changes During Pregnancy
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-01-21
683
Participants Needed
1
Research Sites
310 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Mueller polarimetric colposcopy appears to be a powerful tool for evaluating cervical microstructure modification during pregnancy. Some polarimetric parameters of the uterine cervix can be correlated with the gestational age. The uterine cervix's polarimetric analysis could make it possible to accurately predict the term of childbirth and be used as a screening tool for preterm birth.
CONDITIONS
Official Title
Mueller Polarimetric Colposcopy for High-performance Detection of Cervical Changes During Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult female patient
- Single pregnancy
- Baseline at 20 or more weeks of amenorrhea for low risk group
- Baseline at 20 or more and less than 37 weeks of amenorrhea for high risk group
- Pregnancy dating confirmed by first trimester ultrasound
- Written and informed consent
- Low risk group: asymptomatic patient with usual maternity follow-up
- High risk group: symptomatic patient with cervical changes and cervical length less than 20 mm by ultrasound, or asymptomatic patient with previous premature delivery or late miscarriage and cervical changes with cervical length less than 20 mm
You will not qualify if you...
- Known or suspected uterine malformation
- Multiple pregnancy
- Premature rupture of membranes
- Suspicion of chorioamnionitis
- Heavy active bleeding preventing cervix visualization
- History of conization
- Imminent childbirth
- Medical indications for birth before 37 weeks (severe pre-eclampsia, severe fetal growth restriction, hemorrhagic placenta previa, fetal malformations, etc.)
- Inability to examine cervix under speculum
- Lack of social coverage
- Limited understanding
- Participation in another interventional research
- Low risk group exclusion: history of spontaneous premature labor, late miscarriage, or premature rupture of membranes
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hospital Bicêtre - Gynecology-Obstetrics Department
Le Kremlin-Bicêtre, France, France, 94275
Actively Recruiting
Research Team
D
Dominique LUTON, Pr
CONTACT
A
Angelo PIERANGELO, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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