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Multi-center Clinical Observation and Mechanism Study of Yunnan Baiyao in Different Stages of Diabetic Foot Ulcer
Led by Peking University Third Hospital · Updated on 2024-07-03
100
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Yunnan Baiyao has been treating all kinds of wounds for 120 years, but the evidence of Evidence-based medicine that is truly convincing is insufficient, making its best application method unclear. This study explored the possible indications and use methods of Yunnan Baiyao in different stages of Diabetic foot, and obtained Evidence-based medicine evidence of clinical efficacy. Obtain the discarded tissues of Diabetic foot patients in the treatment and control groups of Yunnan Baiyao after wound debridement, conduct Transcriptome (BulkRNA seq) analysis and detection on the wound tissues, and analyze the related signal pathways and functional genes with significant differences, to help clarify the possible treatment targets of Yunnan Baiyao.
CONDITIONS
Official Title
Multi-center Clinical Observation and Mechanism Study of Yunnan Baiyao in Different Stages of Diabetic Foot Ulcer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years old
- Diagnosed with diabetes according to WHO standards
- Diagnosis of diabetic foot
- Confirmed as one of the stages of infection progression or granulation growth
- Voluntarily agree to participate and sign informed consent
You will not qualify if you...
- Severe uncontrolled diseases such as acute myocardial infarction, heart failure, hepatitis, shock, or respiratory failure
- Uncontrolled blood glucose: fasting blood sugar >15 mmol/L or glycated hemoglobin >12%
- Active bleeding inside the wound preventing routine basic treatment
- Low blood protein or blood cell counts: serum albumin <20 g/L, hemoglobin <60 g/L, or platelets <50 × 10^9/L
- Late-stage malignant tumors
- Active autoimmune disease
- History of allergy to Yunnan Baiyao
- Unable to cooperate or has mental disorders
- Any other condition judged by researchers to affect wound healing or study compliance
AI-Screening
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Trial Site Locations
Total: 1 location
1
Peking University 3rd Hospital
Beijing, China
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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