Actively Recruiting
Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients
Led by Arkansas Children's Hospital Research Institute · Updated on 2025-10-02
2000
Participants Needed
27
Research Sites
346 weeks
Total Duration
On this page
Sponsors
A
Arkansas Children's Hospital Research Institute
Lead Sponsor
S
St. Jude Children's Research Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The participants are being asked to take part in this clinical trial, a type of research study, because the participants are scheduled to receive or have recently received a hematopoietic cell transplant (HCT) or a solid organ transplant (SOT). Primary Objective To determine if pre-transplant screening for respiratory viral load predicts RVI within 1- year post-transplant among survivors. Secondary Objectives: * To develop and validate a classifier based on pre-transplant immunological profile predictive of developing an acute respiratory viral infection (aRVI), with RSV/PIV3/HMPV/SARS-CoV-2 through one-year post-transplant among survivors. * To develop and validate a classifier based on Day +100 post-transplant immunological profiles predictive of developing an acute respiratory viral infection (aRVI),with RSV/PIV3/HMPV/SARS-CoV-2 through one-year post-transplant among survivors .
CONDITIONS
Official Title
Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients
Who Can Participate
Eligibility Criteria
You may qualify if you...
Recipient Inclusion Criteria
-
Less than 18 years at the time of anticipated transplant
-
Participant meets one of the following criteria:
- scheduled to receive allogeneic hematopoietic cell transplant within 14 days of enrollment or
- Scheduled to or received solid organ transplant within 7 days before or after enrollment
-
Participant is receiving care at the time of enrollment at one of the study participating institutions.
-
Parent/guardian willing and able to provide informed consent, and if appropriate, child willing and able to provide informed assent.
Donor Inclusion Criteria
- Donor for HCT recipient enrolled on the VIPER study.
- Willing and able to provide informed consent.
Exclusion Criteria:
Recipient Exclusion Criteria
None
Donor Exclusion Criteria
- Is not an HCT donor for a participant enrolled on the VIPER study.
- Not available to provide pre-transplant research blood sample.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 27 locations
1
University of Alabama at Birmingham's (UAB)
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202
Actively Recruiting
3
Children's National Medical
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
4
University if Miami
Miami, Florida, United States, 33146
Actively Recruiting
5
Emory and Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30322
Actively Recruiting
6
University of Chicago Medicine Comer Children's Hospital
Chicago, Illinois, United States, 60637
Actively Recruiting
7
University of Louisville
Louisville, Kentucky, United States, 40202
Actively Recruiting
8
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
9
C.S. Mott Children's Hospital
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
10
Children's Hospital of Michigan
Detroit, Michigan, United States, 48201
Actively Recruiting
11
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
12
Washington University
St Louis, Missouri, United States, 63105
Actively Recruiting
13
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
14
The Children's Hospital at Montefiore
The Bronx, New York, United States, 10467
Actively Recruiting
15
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
16
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
17
UPMC
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
18
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
19
Le Bonheur Children's Hospital
Memphis, Tennessee, United States, 38103
Actively Recruiting
20
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
21
UT Le Bonheur
Memphis, Tennessee, United States, 38105
Actively Recruiting
22
Cook Children's
Fort Worth, Texas, United States, 76104
Actively Recruiting
23
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
24
MD Anderson Center Center
Houston, Texas, United States, 77030
Actively Recruiting
25
UTHealth Houston
Houston, Texas, United States, 77225-0036
Actively Recruiting
26
Seattle Childrens
Seattle, Washington, United States, 98105
Actively Recruiting
27
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
G
Gabriela Maron, MD
CONTACT
W
William J. Steinbach, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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