Multi Center Clinical Observation of Sentinel Skin Graft From the Same Donor Source for Detecting Acute Rejection After Renal Transplantation

What this Trial Is About

Researchers are exploring the use of sentinel skin grafts taken from the same donor to detect acute rejection after kidney transplantation. This observational study aims to improve the early diagnosis of kidney transplant rejection and provide timing guidance for early immune intervention. It is sponsored by the Second Affiliated Hospital, School of Medicine, Zhejiang University and focuses on patients aged 18 to 60 with end-stage renal disease undergoing kidney transplantation. The study involves performing sentinel skin grafts alongside kidney transplantation from the same donor source. These skin grafts will be monitored to assist in detecting acute rejection of the kidney transplant. Participants will be followed regularly after surgery, with visits weekly in the first month, then every two weeks during months 2 to 3, every four to six months later, and every three months during months 7 to 12. Additional follow-up may occur if signs of skin rejection appear. During the study, researchers will assess kidney transplant rejection using established Banff criteria for kidney and skin tissue, kidney function tests, renal ultrasound, and record any complications. Follow-up will last approximately one year. Participants will undergo regular hospital visits and evaluations to monitor transplant status and overall health as part of this clinical observation.

Multi Center Observation of Sentinel Skin Graft for Detecting Acute Rejection After Renal Transplantation