Actively Recruiting
A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated With Percutaneous Ablation and Palliative Radiation Therapy
Led by Society of Interventional Oncology · Updated on 2026-02-19
120
Participants Needed
6
Research Sites
92 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this study is to evaluate real-world outcomes (e.g., pain, patient reported outcomes, skeletal related events, healthcare utilization, etc.) in patients treated with both percutaneous ablation and palliative radiation therapy (RT).
CONDITIONS
Official Title
A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated With Percutaneous Ablation and Palliative Radiation Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Skeletal metastasis with localized pain not controlled medically with worst pain 65 5 using the BPI within last 24 hours
- Pain must come from one painful metastatic bone lesion (other less painful sites allowed)
- Lesions at high risk of skeletal related events: spinal lesions with SINS score 65 7 or pelvic/appendicular lytic lesions causing functional/mechanical pain
- Target lesion suitable for percutaneous ablation with image guidance and radiation therapy by specialists
- No prior targeted radiation therapy or ablation to the index lesion
- ECOG performance status between 0 and 2
- Age 21 years or older
- Signed informed consent form
- Willing and able to complete follow-up patient-reported outcome surveys for up to 12 months
- Life expectancy greater than 3 months
You will not qualify if you...
- Any medical or personal condition that may affect safety, compliance, or successful completion of the trial
- Target tumor involves weight-bearing long bone of lower extremity with more than 50% cortical bone loss (MIREL Score 65 7)
- Skeletal lesions with unstable pathologic fractures needing immediate surgical stabilization
- Participation in other studies that might affect the primary endpoint
- Target tumor causing clinical or imaging evidence of spinal cord compression
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
University of California San Diego Moores Cancer Center
San Diego, California, United States, 92093
Actively Recruiting
2
Emory University Hospital
Atlanta, Georgia, United States, 30322
Not Yet Recruiting
3
Northside Hospital
Atlanta, Georgia, United States, 30342
Actively Recruiting
4
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
5
Washington University
St Louis, Missouri, United States, 63110
Actively Recruiting
6
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Not Yet Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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