Observational Study to Understand the Progression and Management of Limbal Stem Cell Deficiency in Patients Aged 12 to 99

What this Trial Is About

Researchers are conducting an observational study to track the natural history, clinical course, and management patterns of people with limbal stem cell deficiency LSCD. The study focuses on participants aged 12 to 99 years who have a diagnosis of LSCD. It aims to understand how this condition progresses over time by assessing changes in vision and eye structure without administering any study treatments. Participants will not receive any study drug or product as this is a non-interventional study. Instead, researchers will observe and collect information on the conditions progression and management. The study will follow participants from screening through 84 weeks, monitoring various vision-related and anatomical changes that are associated with LSCD. During the study, participants will undergo regular assessments including patient-reported outcomes and multiple vision tests such as photophobic best corrected visual acuity BCVA, low-luminance BCVA, low-contrast BCVA, and contrast sensitivity. Anatomical changes will also be evaluated through eye examinations over the 84-week period. Researchers will track both functional and structural changes to better understand LSCDs impact and progression in the study population.

Multi-Center, Prospective, Non-Interventional Study in Subjects With Limbal Stem Cell Deficiency