Radiation Effects on Sexual Health in Women With Pelvic Cancers Using Biomarkers and Imaging to Predict Side Effects

What this Trial Is About

Researchers are studying how radiotherapy and other cancer treatments affect sexual function in female cancer patients. The study aims to understand why some patients experience more side effects from radiotherapy than others. This research may help develop ways to predict sexual side effects and improve radiotherapy techniques or interventions to reduce these effects and enhance quality of life for women with cancer. Participants include women with pelvic cancers treated with radiotherapy. The study collects medical record data, quality of life and toxicity questionnaires, blood samples, microbiome samples, and ultrasound imaging over time. Blood and microbiome samples are collected before treatment, after treatment, and periodically for up to two years or longer. Ultrasound imaging is also performed before and after treatment and regularly for two years. Throughout the study, participants provide consent for medical record access and complete questionnaires about their health and side effects. Biological samples and imaging help researchers study genetic, microbiome, and imaging predictors of sexual side effects. The primary measure is sexual quality of life over two years, with additional assessments of dosimetric, imaging, and microbiome predictors. Participants are monitored and asked to continue yearly questionnaires and sample collections as long as they remain in the study.

A Multi Center Study of Sexual Toxicities After Radiotherapy