Actively Recruiting
The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Led by Zhongnan Hospital · Updated on 2026-04-20
150
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
CONDITIONS
Official Title
The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically diagnosed with primary angle-closure glaucoma (PACG)
- Aged 50 years or older, no gender restriction
- Case Group A: Undergoing glaucoma surgery with confirmed significant zonular laxity during surgery
- Case Group B: Undergoing glaucoma surgery with confirmed normal zonular morphology during surgery
- Control group: age- and sex-matched with case groups; diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery
You will not qualify if you...
- Secondary glaucoma
- History of previous intraocular surgery
- Systemic diseases causing abnormal ocular zonules
- Other severe ocular diseases
- Long-term use of medications affecting connective tissue metabolism
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China, 430000
Actively Recruiting
Research Team
M
Min Ke, doctor
CONTACT
X
Xiaomin Chen, doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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