Actively Recruiting
Multi-Omics-Based Prediction of Allograft Dysfunction After Lung Transplantation
Led by Chang Chen · Updated on 2025-11-24
244
Participants Needed
1
Research Sites
225 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
By establishing a prospective, multicenter lung transplantation clinical cohort, this study aims to systematically evaluate the utility of cfDNA fragmentomics, peripheral blood single-cell sequencing, and proteomics in monitoring and predicting graft dysfunction after lung transplantation, and to develop a multi-omics predictive model for early identification, dynamic monitoring, and mechanistic investigation of acute lung allograft dysfunction (ALAD) and chronic lung allograft dysfunction (CLAD).
CONDITIONS
Official Title
Multi-Omics-Based Prediction of Allograft Dysfunction After Lung Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Recipients aged 9 years undergoing single or double lung transplantation
- Postoperative recipients capable of understanding and providing written informed consent, and willing to comply with scheduled follow-ups and sample collections as required by the study
- Postoperative recipients clinically assessed as stable and eligible for routine follow-up and hematological examinations
- Recipients able to undergo dynamic pulmonary function monitoring during follow-up
- No planned participation in other interventional trials during the study period that may impact immune function or pulmonary function
- Retransplant patients will be considered as a new transplant event and may be included in the analysis
You will not qualify if you...
- History of active malignancy or presence of untreated malignancy within 5 years prior to transplantation
- Presence of active systemic infection or significant immune rejection
- Female patients who are pregnant or lactating
- Any other condition deemed by the investigator to be inappropriate for inclusion
AI-Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Pulmonary Hospital
Shanghai, China
Actively Recruiting
Research Team
J
Junqi Wu
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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