Actively Recruiting
Multi-omics Database for Integrative Microbiome Analysis in a Cohort of Korean Patients With Ankylosing Spondylitis
Led by Tae-Hwan Kim · Updated on 2023-11-22
600
Participants Needed
2
Research Sites
221 weeks
Total Duration
On this page
Sponsors
T
Tae-Hwan Kim
Lead Sponsor
K
Kyunghee University Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Multicenter Human Derivatives Prospective Cohort Study: Clinical information will be collected from patients with ankylosing spondylitis and their families who have provided research consent. And clinical samples including blood, saliva, feces, and mucosal biopsy tissue (from patients scheduled for sigmoid colonoscopy or routine colonoscopy examinations) will be collected. Multi-omics data production and laboratory analysis will be conducted using the collected samples, followed by integrated bioinformatic analysis using the produced data."
CONDITIONS
Official Title
Multi-omics Database for Integrative Microbiome Analysis in a Cohort of Korean Patients With Ankylosing Spondylitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with ankylosing spondylitis
- Age between 19 and 60 years at consent
- Diagnosis based on Modified New York criteria or 2010 spondyloarthritis criteria
- Voluntary agreement to participate and follow study requirements
- Family members aged 19 to 65 years
- Must be a primary immediate family member (parent, brother, or sister) living with the patient
- Family members must never have been diagnosed with ankylosing spondylitis
- Family members must voluntarily agree to participate and follow study requirements
You will not qualify if you...
- Ankylosing spondylitis patients who used oral or injected antibiotics within the last 3 months
- Ankylosing spondylitis patients who consumed lactic acid bacteria health foods within the last 3 months
- Family members with recent medication use as defined in the study
- Family members who received a vaccine within 1 month before microbiome collection
- Family members who used topical antibiotics or steroids on specified body areas within 24 hours before microbiome collection
- Family members who used vaginal or vulvar medications within 24 hours before microbiome collection
- Individuals with acute illness at sampling time, unless sampling can be postponed
- Individuals with significant chronic medical conditions affecting major organs or systems
- Individuals with rapid diet changes within 4 weeks before microbiome collection
- Individuals with uncontrolled gastrointestinal disorders or certain digestive diseases
- Individuals needing diapers for urinary incontinence
- Individuals suspected to have conditions that could affect sample collection at the time of microbiome sampling
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Kyung Hee University Medical Center
Seoul, Kyungheedae-ro 23, South Korea, 02447
Actively Recruiting
2
Hanyang University Hospital for Rheumatic Diseases
Seoul, Wangsimni-ro222-1, South Korea, 04763
Actively Recruiting
Research Team
T
Tae-Hwan Kim, MD,PhD
CONTACT
J
Ji-Hui Shin, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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