Actively Recruiting
Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD
Led by The University of Texas at Dallas · Updated on 2025-08-22
330
Participants Needed
3
Research Sites
378 weeks
Total Duration
On this page
Sponsors
T
The University of Texas at Dallas
Lead Sponsor
U
University of Texas Southwestern Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to examine the benefits of combining repetitive Transcranial Magnetic Stimulation (rTMS) coupled with Cognitive Processing Therapy (CPT) in treating combat-related Posttraumatic Stress Disorder (PTSD) symptoms. The study will also examine change in depression, psychosocial functioning, and neurophysiological (i.e., electroencephalography and magnetic resonance images) measures.
CONDITIONS
Official Title
Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans of Post-9/11 military conflicts
- Diagnosis of PTSD based on CAPS-5 related to Post-9/11 military combat
You will not qualify if you...
- Current enrollment in an acute experimental treatment for PTSD or trauma-focused psychotherapy
- PTSD-inducing trauma exposure within 3 months prior to evaluation
- History of epilepsy, seizure disorder, or major head trauma
- Neurologic conditions increasing seizure risk
- Brain tumors
- Moderate to severe substance use disorder in last 3 months or substance use causing significant impairment
- Stroke or blood vessel abnormalities in the brain
- Dementia
- Parkinson's disease, Huntington's chorea, or multiple sclerosis
- High suicide risk
- Lifetime history of psychotic disorder or bipolar disorder
- Inability to stop medications that lower seizure threshold
- Pregnant or nursing
- Metal fragments or objects in or near the head that cannot be safely removed
- History of severe traumatic brain injury or high seizure risk
- History of seizures
- Non-English speakers
- Cardiac pacemaker or implanted medication pumps increasing rTMS risk
- Any medical condition preventing safe participation in rTMS
- Use of medications or substances that lower seizure threshold
- Previous rTMS treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Florida State University College of Medicine
Tallahassee, Florida, United States, 32308
Actively Recruiting
2
Metrocare Services of Dallas
Addison, Texas, United States, 75001
Actively Recruiting
3
The University of Texas at Dallas
Dallas, Texas, United States, 75235
Actively Recruiting
Research Team
E
Elizabeth "Ellen" Morris, PhD
CONTACT
J
Jill Ritter, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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