Actively Recruiting
A Multi-site Study to Evaluate the Persistence of Protective Immunity to Routine Childhood Vaccinations in Participants With B-ALL/Ly Who Have Received Blinatumomab
Led by Arkansas Children's Hospital Research Institute · Updated on 2026-02-25
300
Participants Needed
2
Research Sites
154 weeks
Total Duration
On this page
Sponsors
A
Arkansas Children's Hospital Research Institute
Lead Sponsor
C
Columbia University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to establish a clear vaccination protocol for pediatric patients (less than 21 years old) who have received treatment for B-cell Acute Lymphoblastic Leukemia/Lymphoma. The main study aims are: * Evaluate the persistence of protective immunity to routine childhood vaccinations in participants with B-ALL/Ly who have received blinatumomab. * To determine whether revaccination in participants with non-protective titers leads to restored humoral immunity. Researchers will compare results from participants who have received immunotherapy to those who have not received immunotherapy to see if immunotherapy versus other chemotherapeutic drugs adversely affect the protective immunity acquired through vaccination.
CONDITIONS
Official Title
A Multi-site Study to Evaluate the Persistence of Protective Immunity to Routine Childhood Vaccinations in Participants With B-ALL/Ly Who Have Received Blinatumomab
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of B-lineage acute lymphoblastic leukemia or lymphoma
- Between 1 and 21 years old at diagnosis
- Provided informed consent (and child assent if applicable)
- Completed all vaccinations routinely given during the first year of life
You will not qualify if you...
- Relapsed or refractory disease at any time
- Has received or will require bone marrow transplant or cellular therapy
- Is pregnant
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Arkansas Children's
Little Rock, Arkansas, United States, 72202
Actively Recruiting
2
Arkansas Children's Northwest
Springdale, Arkansas, United States, 72762
Actively Recruiting
Research Team
L
Lauren Appell, MD
CONTACT
S
Stephanie Thomas, RN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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