Actively Recruiting
Multi-Strain Probiotics Supplementation With Standard Care in Mild to Moderate Ulcerative Colitis
Led by National University of Malaysia · Updated on 2025-03-12
124
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Probiotics are one of the adjunctive treatments that have been extensively explored for Ulcerative colitis (UC) disease management. Probiotics, a group of beneficial bacteria, can bring various health benefits when adequately supplied to the body, especially for gut wellness. In particular, for UC patients, gut dysbiosis is one of the contributing factors in their pathogenesis. Thus, the supplementation of probiotics in combination with standard treatment can potentially help in relieving symptoms as well as promoting mucosal healing for long-term remission.
CONDITIONS
Official Title
Multi-Strain Probiotics Supplementation With Standard Care in Mild to Moderate Ulcerative Colitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Ulcerative Colitis confirmed by colonoscopy and consistent histology
- Ulcerative Colitis involving at least the rectosigmoid confirmed by colonoscopy at study start
- Mild to moderate disease activity with a partial Mayo score between 3 and 8
- Use of medication for at least 4 weeks before the study
You will not qualify if you...
- Diagnosis of Crohn's disease or pouchitis
- Severe disease activity with a partial Mayo score above 8
- Use of antibiotics within 2 weeks before study entry
- Change in medication dose within 4 weeks before study entry or during the 12-week study period
- Use of probiotics within 2 weeks before study entry
- Use of NSAIDs within 1 week before and during the 12-week study period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital Canselor Tuanku Muhriz UKM
Cheras, Kuala Lumpur, Malaysia, 56000
Actively Recruiting
Research Team
N
Norfilza M Mokhtar, MD, MMedSci, PhD
CONTACT
R
Raja Affendi Raja Ali, MBBChBaO,MD,MMedSci,MBA,CCST
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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