Actively Recruiting
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Led by Xiaojuan Li · Updated on 2026-02-27
88
Participants Needed
1
Research Sites
247 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health. Towards this goal, extensive efforts are ongoing to develop quantitative MRI for cartilage matrix analysis. MR T1ρ and T2 relaxation times have shown to be promising imaging biomarkers for early cartilage degeneration and prediction of disease progression. However, many challenges remain to clinically applying these techniques, including lack of standardized acquisition and quantification methods, and long acquisition times. The study aims to develop novel, fast and reproducible MR T1ρ and T2 relaxation time imaging methods on MR systems from multiple vendors and establish a platform for standardization and cross validation of these measures as a tool for clinical trials using such techniques. Following method validation, patients at risk for osteoarthritis will be tested.
CONDITIONS
Official Title
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years for Group 1
- Age between 18 and 50 years for Groups 2, 3, and 4
- Sustained an acute full ACL tear in one knee with the other knee uninjured for Group 3
- Undergoing ACL reconstruction and standard rehabilitation for Group 3
- Age between 18 and 50 years for controls matched by age, sex, and BMI for Group 4
You will not qualify if you...
- Contraindication to MRI such as severe claustrophobia or implanted devices (neurostimulators, pacemakers, aneurysm clips) for all groups
- Pregnancy for all groups
- History of osteoarthritis and inflammatory arthritis for Groups 2 and 4
- Previous injury or surgery on either knee for Groups 2 and 4
- Inability to undergo standard pre- and post-injury or operative rehabilitation for Group 3
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
X
Xiaojuan Li, PhD
CONTACT
J
Jennifer Baldwin
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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