Clinical epidemiology of central venous catheter-related bloodstream infections in an intensive care unit in China.
Songlin Peng, Yan Lu
https://pubmed.ncbi.nlm.nih.gov/23265289Actively Recruiting
Phase Not Applicable
All Genders
Healthy Volunteers
ID06085690
Multicenter Clinical Translational Study of ICU-NO CRBSI Based on Improvement Science in China
Led by Fudan University · Updated on 2025-11-17
8050
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
Sponsors
F
Fudan University
Lead Sponsor
F
Fudan University Evidence-based Nursing Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a multicenter clinical translational study called "ICU-NO CRBSI" to evaluate continuous quality improvement methods aimed at preventing catheter-related bloodstream infections (CRBSI) in Intensive Care Units (ICUs). The study focuses on measuring the incidence of CRBSI in participating ICUs, assessing healthcare providers' adherence to evidence-based practices, and understanding what support is needed to implement safety improvements. This study is a cluster-randomized controlled trial involving 23 medical centers and approximately 23,000 catheter days from about 8,050 patients. It compares routine central venous catheter (CVC) care with an evidence-based intervention program designed to prevent CRBSI. The study includes a baseline phase, a control phase, and an intervention phase with two rounds of quality improvement and follow-up periods to assess the intervention's impact and sustainability. Participants are ICU patients with CVCs placed for more than 24 hours and stays longer than 48 hours. Researchers collect data on CRBSI incidence, ICU stay length, mortality related to bloodstream infections, hospitalization costs, and adherence to care guidelines. The study monitors outcomes over one year through regular reporting, aiming to verify intervention effects and promote continuous quality improvement in ICUs.
CONDITIONS
Brief Title
Multicenter Clinical Translational Study of "ICU-NO CRBSI" Based on Improvement Science
Who Can Participate
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- ICU stay over 48 hours
- Central venous catheter placed for more than 24 hours
You will not qualify if you...
- Pregnant patients
- Patients with a history of catheter-related bloodstream infection
- Patients with central venous catheterization brought in from other hospitals
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Outpatient Treatment
Duration - Up to 9 months
Participants receive routine care or the evidence-based intervention plan aimed at preventing catheter-related bloodstream infections in ICU patients.
Visits occur throughout ICU stay as per routine care and intervention protocols
Follow-up
Duration - Up to 3 months after treatment phase
Participants are observed to assess the sustainability and effect of the intervention after the active treatment phase.
Ongoing monitoring during ICU stay and data collection visits
Trial Site Locations
Total: 1 location
1
ZhongShan Hospital Affilicated to Fudan University
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
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Research Team
C
CHUNLEI Li
Y
YuXia Zhang
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/17192537Eliminating central line-associated bloodstream infections: a national patient safety imperative.
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https://pubmed.ncbi.nlm.nih.gov/24334799