Multicenter Study to Improve Prevention of Catheter-Related Bloodstream Infections in ICU Patients Using Evidence-Based Care

What this Trial Is About

Researchers are conducting a multicenter clinical translational study called ICU-NO CRBSI to evaluate continuous quality improvement methods aimed at preventing catheter-related bloodstream infections CRBSI in Intensive Care Units ICUs. The study focuses on measuring the incidence of CRBSI in participating ICUs, assessing healthcare providers adherence to evidence-based practices, and understanding what support is needed to implement safety improvements. This study is a cluster-randomized controlled trial involving 23 medical centers and approximately 23,000 catheter days from about 8,050 patients. It compares routine central venous catheter CVC care with an evidence-based intervention program designed to prevent CRBSI. The study includes a baseline phase, a control phase, and an intervention phase with two rounds of quality improvement and follow-up periods to assess the interventions impact and sustainability. Participants are ICU patients with CVCs placed for more than 24 hours and stays longer than 48 hours. Researchers collect data on CRBSI incidence, ICU stay length, mortality related to bloodstream infections, hospitalization costs, and adherence to care guidelines. The study monitors outcomes over one year through regular reporting, aiming to verify intervention effects and promote continuous quality improvement in ICUs.

Multicenter Clinical Translational Study of "ICU-NO CRBSI" Based on Improvement Science