Prospective Multicenter Study of ANCA-Associated Vasculitis Progression and Outcomes in Hunan, China

What this Trial Is About

Researchers are investigating the incidence and progression of Anti-neutrophil cytoplasmic antibody ANCA associated vasculitis AAV and its link to serious outcomes like end stage renal disease ESRD and death. This multicenter prospective cohort study will enroll about 500 patients with AAV from Hunan province, China, to better understand the disease over time. Participants will have a baseline visit where demographic information, medical and family history, medication use, lifestyle factors, physical activity, and body measurements are collected. Laboratory tests and imaging exams will also be performed. After the initial visit, participants will be followed annually for at least 5 years, with similar evaluations and sample collections at each follow-up. During the study, researchers will monitor major outcomes including ESRD and death, classified by causes such as cardiac, infectious, or renal reasons. Data collected at baseline and follow-ups will include clinical and laboratory information to assess disease activity and adverse events over time. The total participation duration is planned to be five years or until death, starting renal replacement therapy, or dropout.

Multicenter Cohort Study of AAV in Hunan of China