Actively Recruiting
Multicenter Cohort Study of ANCA-associated Small Vasculitis in Hunan Province of China
Led by Xiangya Hospital of Central South University · Updated on 2022-04-07
500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
X
Xiangya Hospital of Central South University
Lead Sponsor
C
Central South University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the incidence and progression of Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) and its link to serious outcomes like end stage renal disease (ESRD) and death. This multicenter prospective cohort study will enroll about 500 patients with AAV from Hunan province, China, to better understand the disease over time. Participants will have a baseline visit where demographic information, medical and family history, medication use, lifestyle factors, physical activity, and body measurements are collected. Laboratory tests and imaging exams will also be performed. After the initial visit, participants will be followed annually for at least 5 years, with similar evaluations and sample collections at each follow-up. During the study, researchers will monitor major outcomes including ESRD and death, classified by causes such as cardiac, infectious, or renal reasons. Data collected at baseline and follow-ups will include clinical and laboratory information to assess disease activity and adverse events over time. The total participation duration is planned to be five years or until death, starting renal replacement therapy, or dropout.
CONDITIONS
Brief Title
Multicenter Cohort Study of AAV in Hunan of China
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Fulfill 2012 criteria of ANCA associated vasculitis
- Agree to sign informed consent
You will not qualify if you...
- Do not agree to sign informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo a baseline visit to collect detailed demographics, medical and family history, medication history, health behaviors, physical activity, anthropometric measures, and laboratory parameters.
1 baseline visit (in-person)
Duration - At least 5 years
Participants are followed annually for at least 5 years to evaluate clinical outcomes including disease activity, adverse events, and progression to end stage renal disease or death. Follow-up assessments include similar evaluations and sample collections as the baseline visit.
Annual follow-up visits
Trial Site Locations
Total: 1 location
1
Xiangya hospital
Changsha, Hunan, China, 410008
Actively Recruiting
Research Team
Y
Yong Zhong, doctor
T
Ting Meng, doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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