Actively Recruiting
Multicenter iTBS Neuromodulation for PTSD Treatment
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2026-04-24
140
Participants Needed
5
Research Sites
134 weeks
Total Duration
On this page
Sponsors
S
Second Affiliated Hospital, School of Medicine, Zhejiang University
Lead Sponsor
S
Shanghai Mental Health Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The proposed study aims to evaluate the efficacy of intermittent theta-burst transcranial magnetic stimulation (iTBS) targeting primary motor cortex (M1) as adjunct treatment for PTSD patients. The primary outcome measure includes changes in PTSD symptom severity, with secondary outcome measures focusing on negative moods improvements, quality of life and social/occupation functioning and functional connectivity of the brain.
CONDITIONS
Official Title
Multicenter iTBS Neuromodulation for PTSD Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 18 to 65 years old
- Right handedness
- Have a diagnosis of PTSD meeting DSM-5 criteria
- CAPS-5 score >35
- Under stable medication for at least four weeks
- Capable of independently reading and understanding study materials and providing informed consent.
You will not qualify if you...
- Current or past significant neurological or medical disorder including seizure disorder, CNS tumors, stroke, or cerebral aneurysm
- Primary psychotic disorder, bipolar I disorder, major depressive disorder, or personality disorders
- Lifetime history of attempted suicide or high suicide risk based on HAMD-17 item
- Implanted brain device or metal implants, pacemaker, extensive dental work, or magnetic metal implants and upper body tattoos if undergoing fMRI
- Previous experience with repetitive transcranial magnetic stimulation (rTMS)
- Pregnancy, lactation, or planning pregnancy during the study
- Currently receiving psychological or other physical treatments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China
Actively Recruiting
2
First Affiliated Hospital of Anhui Medical University
Hangzhou, Zhejiang, China
Actively Recruiting
3
Second Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Actively Recruiting
4
The Affiliated Kangning Hospital of Ningbo University
Ningbo, Zhejiang, China
Actively Recruiting
5
Tongji Hospital of Tongji University
Shanghai, China
Actively Recruiting
Research Team
H
Huiqian Huang, Ph.D.
CONTACT
S
Shanshan Li, Bachelor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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