Actively Recruiting
A Multicenter, Open-label, Single-arm, Phase II Study of NHWD-870 HCl in Adults and Adolescents with Advanced NUT Cancer
Led by Zhejiang Wenda Pharma Technology LTD. · Updated on 2025-01-24
48
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multicenter, open-label, single-arm, phase II study to evaluate the efficacy, safety, and pharmacokinetics of NHWD-870 HCl in adults and adolescents with advanced NUT cancer.
CONDITIONS
Official Title
A Multicenter, Open-label, Single-arm, Phase II Study of NHWD-870 HCl in Adults and Adolescents with Advanced NUT Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed written informed consent before study procedures
- Willingness and ability to comply with study visits, treatment, and tests
- For participants under 18, signed agreement from participant and legal guardian
- Male or female aged 18 to 75 years (adults) or 12 to under 18 years (adolescents)
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2
- Expected survival of at least 3 months
- Histopathological diagnosis of midline (NUT) cancer confirmed by tests such as IHC, FISH, or DNA/RNA sequencing within the last 3 years
You will not qualify if you...
- Previous treatment with a BET inhibitor
- Diagnosis of other malignant tumors within 3 years, except treated basal cell carcinoma, bladder cancer, or cervical carcinoma in situ
- Need for systemic anti-infection treatment due to active infection
- Clinically significant bleeding or bleeding tendency within 3 months before enrollment
- Tumor invasion of important blood vessels or risk of fatal hemorrhage during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Three Gorges Hospital Affiliated to Chongqing University
Chongqing, China, 404100
Actively Recruiting
Research Team
C
Chao Deng, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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