Actively Recruiting
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Led by Peking University Third Hospital · Updated on 2024-05-16
2000
Participants Needed
11
Research Sites
N/A
Total Duration
On this page
Sponsors
P
Peking University Third Hospital
Lead Sponsor
F
First Affiliated Hospital, Sun Yat-Sen University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a large prospective cohort study called the ChiTwiMC Cohort to investigate serious complications and adverse outcomes related to twin pregnancies in China. The study aims to follow twin maternal-child pairs from early pregnancy through neonatal periods and into early childhood. This research is supported by the National Key Research and Development Program of China and led by experts at Peking University Third Hospital. The study plans to enroll 2,000 pregnant women aged 18 to 45 years with twin pregnancies before 14 weeks of gestation. Participants will receive regular follow-up visits at 22-28 weeks, 30-38 weeks, delivery, and postpartum at 42 days, 6 months, and 12 months. During these stages, researchers will collect detailed clinical data and biological samples including blood, hair, cervicovaginal secretions, placenta tissue, amniotic fluid, umbilical cord blood, meconium, infant buccal mucosa, and paternal blood. Participants will provide information on demographics, medical and reproductive history, clinical diagnoses, treatments, and pregnancy and birth outcomes through an electronic system. The study will monitor rates of complications such as preterm delivery, preeclampsia, twin-to-twin transfusion syndrome, fetal growth restriction, brain injury, and early childhood developmental delays. Children's growth measurements will also be tracked within the first year after birth. This observation will continue through delivery and the first year postpartum to gather comprehensive maternal and child health data.
CONDITIONS
Brief Title
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Twin pregnancies
- Female aged between 18-45 years
- Gestational age is less than 14 weeks
- Planning to receive prenatal healthcare and delivery service at the study hospital
- Signing informed concent and willing to participate
You will not qualify if you...
- Women with mental disorders or serious maternal illness that is not eligible to participate
- Inability to provide informed consent
- Pregnant women not registered in our hospital
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - Up to 14 weeks of gestation
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - From enrollment up to delivery (up to approximately 26 weeks)
Participants are monitored during pregnancy to track maternal and fetal health and collect biological samples.
Visits at 22-28 weeks and 30-38 weeks of gestation, and at delivery
Duration - Up to 12 months after delivery
Participants and their children are followed postpartum to monitor health and development.
Visits at 42 days, 6 months, and 12 months after delivery
Trial Site Locations
Total: 11 locations
1
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China, 230001
Actively Recruiting
2
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191
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3
Peking University
Beijing, Beijing Municipality, China, 10091
Actively Recruiting
4
Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400010
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5
First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China, 510000
Actively Recruiting
6
Shengjing Hospital
Shenyang, Liaoning, China, 110000
Actively Recruiting
7
Shandong Provincial Hospital
Jinan, Shandong, China, 250021
Actively Recruiting
8
The Second Hospital of Shandong University
Jinan, Shandong, China, 250033
Actively Recruiting
9
International Peace Maternity and Child Health Hospital
Shanghai, Shanghai Municipality, China, 200030
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10
Shanghai First Maternity and Infant Hospital
Shanghai, Shanghai Municipality, China, 201204
Actively Recruiting
11
Nankai University
Tianjin, Tianjin Municipality, China, 300071
Actively Recruiting
Research Team
Y
Yuan Wei, PhD, MD
T
Tianchen Wu, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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