Actively Recruiting
Multicenter Prospective Observational Study of Cardiotoxicity in Patients Receiving Targeted Cancer Therapies
Led by Sixth Affiliated Hospital, Sun Yat-sen University · Updated on 2025-12-29
5000
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will prospectively monitor cancer patients receiving chemotherapy (including molecular targeted therapies) for cardiovascular adverse events using biomarkers and imaging. The goal is to develop a predictive model for major adverse cardiovascular events (MACE) in this population by integrating both local factors (e.g. central venous catheter-related thrombosis) and systemic factors (e.g. age, comorbidities, genetic predisposition). An active surveillance system employing periodic cardiac evaluations (ECG, echocardiography) and biomarker measurements (troponin T, NT-proBNP) will enable early detection of cardiotoxic effects. The impact of these adverse events and the monitoring strategy on patients' quality of life will also be assessed.
CONDITIONS
Official Title
Multicenter Prospective Observational Study of Cardiotoxicity in Patients Receiving Targeted Cancer Therapies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults over 18 years old with a confirmed diagnosis of any type of cancer
- Currently receiving or planning to receive chemotherapy including molecular targeted drugs as adjuvant treatment
- Willing and able to provide informed consent and clinical data and biological samples for the study
You will not qualify if you...
- Missing key patient information or medical records needed for the study
- Did not complete the full planned chemotherapy course at the study center
- History of severe acute cardiovascular or cerebrovascular events within 6 months before enrollment, such as acute heart failure, heart attack, stroke, malignant arrhythmia, or severe heart failure (NYHA Class IV/V)
- Did not complete essential pre- or post-chemotherapy tests including blood routine, liver/kidney function, coagulation, cardiac enzymes (troponin T), NT-proBNP (or BNP), 12-lead ECG, and echocardiogram
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 5106555
Actively Recruiting
Research Team
X
xiaoyan li
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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