Actively Recruiting
Multicenter Retrospective Observational Study of Relapsed Diffuse Large B-Cell Lymphoma Presenting as Indolent Lymphoma
Led by Azienda USL Reggio Emilia - IRCCS · Updated on 2026-05-05
50
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Most relapses of diffuse large B-cell lymphoma (DLBCL) occur as high-grade lymphoma within the first two years after diagnosis. Relapses as indolent lymphoma are rare events, and the true incidence of this phenomenon is unknown, since literature data are scarce/ and usually restricted to case reports. Analogously, reported treatment strategies are rather heterogeneous, since no standard of care is established and advanced age together with previous anthracycline exposure may narrow the therapeutic choice. The goal of this observational study is to assess epidemiological, clinical characteristics and survival of diffuse large b-cell lymphoma (DLBCL) relapsing as indolent lymphoma. More precisely, the study aims at identifying diagnostic and imaging features associated with relapse as indolent lymphoma and at evaluating disease response to selected therapies.
CONDITIONS
Official Title
Multicenter Retrospective Observational Study of Relapsed Diffuse Large B-Cell Lymphoma Presenting as Indolent Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older at the time of diagnosis.
- Previous diagnosis of diffuse large B-cell lymphoma with or without an indolent B-cell lymphoma component, or DLBCL transformed from indolent B-cell lymphoma.
- First-line treatment for diffuse large B-cell lymphoma.
- Histologically confirmed relapse of indolent B-cell lymphoma diagnosed between 2010 and 2020.
- Availability of histological report of the relapse.
- Availability of clinical and laboratory data from both initial diagnosis and relapse.
- Availability of follow-up data.
- Consent to participate and signed informed consent form (for living and/or contactable patients).
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 1 location
1
Azienda USL IRCCS di Reggio Emilia
Reggio Emilia, Italy
Actively Recruiting
Research Team
A
Attilio Gennaro, Clinical Research Coordinator
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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