Actively Recruiting
A Multicenter Study on Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy: Definition, Prevalence, and Prognostic Impact.
Led by Medical University of Vienna · Updated on 2025-02-19
600
Participants Needed
8
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this prospective registry study is to comprehensively characterize the prevalence, (semi-) quantitative parameters, and associated clinical outcomes of mitral (MR) and tricuspid regurgitation (TR) in patients diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM). The study further aims to develop and implement new grading standards for the quantitative assessment of regurgitation severity, tailored to the distinct hemodynamic profile of ATTR-CM. This approach seeks to address the limitations of current regurgitation severity classifications, which do not adequately reflect the unique pathophysiology of a restrictive phenotype as seen in ATTR-CM.
CONDITIONS
Official Title
A Multicenter Study on Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy: Definition, Prevalence, and Prognostic Impact.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) based on current criteria
- Comprehensive baseline echocardiographic assessment including mitral and tricuspid regurgitation parameters performed within ±6 months of diagnosis
- Age 18 years or older
- Willingness to participate in the study and provide informed consent
You will not qualify if you...
- Severe aortic valve disease requiring intervention
- Inability to provide informed consent or participate in study follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Medical University of Graz
Graz, Styria, Austria, 8010
Actively Recruiting
2
Department of Internal Medicine II, Medical University of Vienna
Vienna, Austria, 1090
Actively Recruiting
3
Medizinische Klinik und Poliklinik I, Klinikum der Universitaet Muenchen, Ludwig-Maximilians-University
Munich, Bavaria, Germany, 81377
Actively Recruiting
4
Department of Cardiology, University Hospital Frankfurt, Goethe University
Frankfurt am Main, Hesse, Germany, 60596
Actively Recruiting
5
Institute of Cardiology, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia
Brescia, Italy, 25100
Actively Recruiting
6
Cardiologic Centre, Azienda Ospedaliero Universitaria di Ferrara
Ferrara, Italy, 44121
Actively Recruiting
7
Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste
Trieste, Italy, 34100
Actively Recruiting
8
University Medical Center Utrecht
Utrecht, Netherlands, 3450
Actively Recruiting
Research Team
C
Christian Nitsche, Priv.-Doz. Dr., PhD
CONTACT
L
Laurenz Hauptmann, Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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