Actively Recruiting
A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke
Led by Nanfang Hospital, Southern Medical University · Updated on 2024-09-05
400
Participants Needed
1
Research Sites
256 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Through a multicenter prospective AIS cohort study, we analyze the potential association of human proteome, microbiome and metabolome alterations with AIS prognosis, searching for key proteins, differential organisms and metabolites, combining experimental data at multiple molecular levels with computational models, and establishing early prediction models through machine learning-based prediction algorithms. While closely tracking the recurrence of stroke in AIS patients, we evaluate the predictive value of human proteome, microbiome and metabolites for stroke recurrence through a nested case-control study, which provides key reference information for exploring the unknown residual risk of AIS recurrence.
CONDITIONS
Official Title
A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with acute ischemic stroke according to Chinese guidelines
- Aged between 18 and 75 years
- Stroke occurred within 7 days before enrollment
- Provide informed consent and medical history
- Able to provide biological specimens
You will not qualify if you...
- Severe impairment of consciousness (NIHSS awareness score >1)
- History of stroke within the last 12 months
- Severe systemic diseases including cancer
- Liver enzymes (ALT or AST) over twice the normal limit or severe liver disease
- Kidney function creatinine over 1.5 times the normal limit or severe kidney disease
- Long-term alcohol use or recent heavy drinking
- History of intestinal tumors, irritable bowel syndrome, or inflammatory bowel disease
- Unable to provide stool sample within 4 days of hospital admission
- Deemed unsuitable for participation by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Nanfang Hospital,Southern Medical University
Guangzhou, Guangdong, China, 510515
Actively Recruiting
Research Team
J
Jia Yin, M.D
CONTACT
W
Weike Hu, M.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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