Actively Recruiting

Phase 3
Age: 5Years - 17Years
All Genders
NCT06690398

Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder in Pediatric Patients

Led by Intra-Cellular Therapies, Inc. · Updated on 2025-07-04

174

Participants Needed

37

Research Sites

122 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients aged 5 to 17 years with a primary diagnosis of irritability associated with Autism Spectrum Disorder (ASD) based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Text Revision (DSM-5-TR) and confirmed by the Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL).

CONDITIONS

Official Title

Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder in Pediatric Patients

Who Can Participate

Age: 5Years - 17Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient has a legally authorized representative willing to provide safety and condition information and attend visits
  • Legally authorized representative must provide written informed consent
  • Patient should provide written assent when developmentally appropriate
  • Male or female aged 5 to 17 years, currently only ages 13 to 17 eligible for enrollment
  • Primary diagnosis of Autism Spectrum Disorder (ASD) confirmed by DSM-5-TR and K-SADS-PL
  • Aberrant Behavior Checklist-Irritability subscale score greater than 18 at screening and baseline
  • Clinical Global Impression-Severity score greater than 4 for irritability related to ASD at screening and baseline
Not Eligible

You will not qualify if you...

  • Primary psychiatric diagnosis other than ASD, except ADHD if stable on medication for 30 days before screening and expected to remain stable
  • Severe and profound intellectual disability; mild and moderate intellectual disability allowed
  • History or current diagnosis of Rett syndrome or Fragile X syndrome
  • Significant risk for suicidal behavior including positive suicidal ideation on C-SSRS items 3, 4, or 5 within 6 months before screening or since screening at baseline
  • One or more suicide attempts within 2 years before screening
  • Considered an imminent danger to self or others by investigator

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 37 locations

1

Clinical Site

Dothan, Alabama, United States, 36303

Actively Recruiting

2

Clinical Site

Peoria, Arizona, United States, 85382

Not Yet Recruiting

3

Clinical Site

Phoenix, Arizona, United States, 85006

Actively Recruiting

4

Clinical Site

Anaheim, California, United States, 92805

Actively Recruiting

5

Clinical Site

Buena Park, California, United States, 90621

Not Yet Recruiting

6

Clinical Site

Corona, California, United States, 92879

Not Yet Recruiting

7

Clinical Site

Oceanside, California, United States, 92056

Actively Recruiting

8

Clinical Site

Redlands, California, United States, 92373

Actively Recruiting

9

Clinical Site

Upland, California, United States, 91786

Actively Recruiting

10

Clinical Site

West Covina, California, United States, 91790

Actively Recruiting

11

Clinical Site

Colorado Springs, Colorado, United States, 80910

Actively Recruiting

12

Clinical Site

Gainesville, Florida, United States, 32607

Actively Recruiting

13

Clinical Site

Jacksonville, Florida, United States, 32258

Actively Recruiting

14

Clinical Site

Miami, Florida, United States, 33125

Actively Recruiting

15

Clinical Site

Miami, Florida, United States, 33175

Actively Recruiting

16

Clinical Site

Miami, Florida, United States, 33176

Actively Recruiting

17

Clinical Site

Miami, Florida, United States, 33186

Actively Recruiting

18

Clinical Site

Miami Lakes, Florida, United States, 33016

Actively Recruiting

19

Clinical Site

Miami Springs, Florida, United States, 33166

Actively Recruiting

20

Clinical Site

West Palm Beach, Florida, United States, 33407

Actively Recruiting

21

Clinical Site

Savannah, Georgia, United States, 31405

Actively Recruiting

22

Clinical Site

Arlington Heights, Illinois, United States, 60005

Not Yet Recruiting

23

Clinical Site

Springfield, Illinois, United States, 62701

Actively Recruiting

24

Clinical Site

Boston, Massachusetts, United States, 02114

Not Yet Recruiting

25

Clinical Site

Saint Charles, Missouri, United States, 63304

Actively Recruiting

26

Clinical Site

Las Vegas, Nevada, United States, 89128

Actively Recruiting

27

Clinical Site

Cincinnati, Ohio, United States, 45229

Not Yet Recruiting

28

Clinical Site

Garfield, Ohio, United States, 44125

Actively Recruiting

29

Clinical Site

Westlake, Ohio, United States, 44145

Actively Recruiting

30

Clinical Site

Nashville, Tennessee, United States, 37203

Actively Recruiting

31

Clinical Site

Dallas, Texas, United States, 75251

Not Yet Recruiting

32

Clinical Site

Frisco, Texas, United States, 75034

Not Yet Recruiting

33

Clinical Site

Houston, Texas, United States, 77089

Actively Recruiting

34

Clinical Site

Plano, Texas, United States, 75093

Actively Recruiting

35

Clinical Site

Richmond, Texas, United States, 77407

Actively Recruiting

36

Clinical Site

Petersburg, Virginia, United States, 23805

Actively Recruiting

37

Clinical Site

Bellevue, Washington, United States, 98007

Actively Recruiting

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Research Team

I

ITI Clinical Trials

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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