Actively Recruiting

Phase 3
Age: 5Years - 17Years
All Genders
NCT06706674

Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric Patients

Led by Intra-Cellular Therapies, Inc. · Updated on 2025-07-08

174

Participants Needed

39

Research Sites

120 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients aged 5 to 17 years with a primary diagnosis of irritability associated with Autism Spectrum Disorder (ASD) based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Text Revision (DSM-5-TR) and confirmed by the Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL).

CONDITIONS

Official Title

Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric Patients

Who Can Participate

Age: 5Years - 17Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • The patient has a legally authorized representative (such as a parent or guardian) willing to provide information and accompany the patient to visits
  • The legally authorized representative must provide written informed consent
  • When appropriate, the patient should provide written assent
  • Male or female patients aged 5 to 17 years (currently only those aged 13 to 17 years are eligible for enrollment)
  • Diagnosis of Autism Spectrum Disorder according to DSM-5-TR confirmed by K-SADS-PL
  • Aberrant Behavior Checklist - Irritability subscale score greater than 18 at screening and baseline
  • Clinical Global Impression-Severity score greater than 4 for irritability associated with ASD at screening and baseline
Not Eligible

You will not qualify if you...

  • Primary psychiatric diagnosis other than Autism Spectrum Disorder (exceptions: ADHD on stable medication regimen for at least 30 days prior to screening)
  • Severe or profound intellectual disability (mild and moderate intellectual disability allowed)
  • History or current diagnosis of Rett syndrome or Fragile X syndrome
  • Significant risk of suicidal behavior as judged by the investigator
  • Suicidal ideation or attempts within specified recent timeframes based on Columbia-Suicide Severity Rating Scale
  • Considered an imminent danger to self or others by the investigator

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 39 locations

1

Clinical Site

Little Rock, Arkansas, United States, 72204

Actively Recruiting

2

Clinical Site

Imperial, California, United States, 92251

Not Yet Recruiting

3

Clinical Site

Sacramento, California, United States, 95817

Not Yet Recruiting

4

Clinical Site

Sherman Oaks, California, United States, 91403

Actively Recruiting

5

Clinical Site

New Haven, Connecticut, United States, 06511

Not Yet Recruiting

6

Clinical Site

Hialeah, Florida, United States, 33012

Actively Recruiting

7

Clinical Site

Miami, Florida, United States, 33122

Actively Recruiting

8

Clinical Site

Miami, Florida, United States, 33130

Actively Recruiting

9

Clinical Site

Miami, Florida, United States, 33144

Actively Recruiting

10

Clinical Site

Miami, Florida, United States, 33165

Actively Recruiting

11

Clinical Site

Miami, Florida, United States, 33173

Actively Recruiting

12

Clinical Site

Miami Gardens, Florida, United States, 33056

Actively Recruiting

13

Clinical Site

Miami Lakes, Florida, United States, 33014

Actively Recruiting

14

Clinical Site

Orlando, Florida, United States, 32803

Actively Recruiting

15

Clinical Site

Orlando, Florida, United States, 32809

Actively Recruiting

16

Clinical Site

Pompano Beach, Florida, United States, 33060

Actively Recruiting

17

Clinical Site

Atlanta, Georgia, United States, 30318

Actively Recruiting

18

Clinical Site

Lawrenceville, Georgia, United States, 30046

Actively Recruiting

19

Clinical Site

Naperville, Illinois, United States, 60563

Actively Recruiting

20

Clinical Site

Evansville, Indiana, United States, 47713

Not Yet Recruiting

21

Clinical Site

Indianapolis, Indiana, United States, 46202

Actively Recruiting

22

Clinical Site

Boston, Massachusetts, United States, 02115

Not Yet Recruiting

23

Clinical Site

Bloomfield Hills, Michigan, United States, 48302

Actively Recruiting

24

Clinical Site

St Louis, Missouri, United States, 63108

Not Yet Recruiting

25

Clinical Site

Lincoln, Nebraska, United States, 68526

Actively Recruiting

26

Clinical Site

Orangeburg, New York, United States, 10962

Actively Recruiting

27

Clinical Site

Staten Island, New York, United States, 10314

Actively Recruiting

28

Clinical Site

The Bronx, New York, United States, 10467

Actively Recruiting

29

Clinical Site

Kinston, North Carolina, United States, 28504

Not Yet Recruiting

30

Clinical Site

Avon Lake, Ohio, United States, 44012

Actively Recruiting

31

Clinical Site

Oklahoma City, Oklahoma, United States, 73116

Actively Recruiting

32

Clinical Site

Charleston, South Carolina, United States, 29425

Not Yet Recruiting

33

Clinical Site

Austin, Texas, United States, 78759

Actively Recruiting

34

Clinical Site

Coppell, Texas, United States, 75019

Not Yet Recruiting

35

Clinical Site

Dallas, Texas, United States, 75251

Actively Recruiting

36

Clinical Site

Fort Worth, Texas, United States, 76104

Actively Recruiting

37

Clinical Site

Houston, Texas, United States, 77090

Actively Recruiting

38

Clinical Site

Richmond, Virginia, United States, 23220

Actively Recruiting

39

Clinical Site

Everett, Washington, United States, 98201

Actively Recruiting

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Research Team

I

ITI Clinical Trials

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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