Actively Recruiting
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
Led by Novartis Pharmaceuticals · Updated on 2026-04-15
502
Participants Needed
139
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.
CONDITIONS
Official Title
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 50 to under 80 years
- Lipoprotein(a) level of 175 nmol/L or higher at screening
- Diagnosis of mild or moderate calcific aortic valve stenosis
- Optimally treated for existing cardiovascular risk factors at randomization
You will not qualify if you...
- Severe calcific aortic valve stenosis
- Uncontrolled hypertension
- History of any malignancy
- History of hemorrhagic stroke or major bleeding
- Platelet count below the lower limit of normal
- Active liver disease or liver dysfunction
- Significant kidney disease
- Pregnant or nursing women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 139 locations
1
Heart Center Research Llc
Huntsville, Alabama, United States, 35801
Actively Recruiting
2
Cardiovascular Res Found
Beverly Hills, California, United States, 90210
Actively Recruiting
3
National Heart Institute
Beverly Hills, California, United States, 90211
Actively Recruiting
4
Flourish Clinical Resrch Covin
Covina, California, United States, 91723
Actively Recruiting
5
Valley Clinical Trials
Northridge, California, United States, 91325
Actively Recruiting
6
Stanford University Medical Center
Palo Alto, California, United States, 94304
Actively Recruiting
7
University Of California San Diego
San Diego, California, United States, 92103-8415
Actively Recruiting
8
UC San Francisco Medical Center
San Francisco, California, United States, 94143
Actively Recruiting
9
Excel Medical Clinical Trials LLC
Boca Raton, Florida, United States, 33434
Withdrawn
10
Nova Clinical Research LLC
Bradenton, Florida, United States, 34209
Actively Recruiting
11
Flourish Res Acq LLC North Miami
Miami, Florida, United States, 33138
Actively Recruiting
12
Inpatient Research Clinical LLC
Miami Lakes, Florida, United States, 33014
Actively Recruiting
13
Advanced Research for Health Improvement LLC
Naples, Florida, United States, 34102
Active, Not Recruiting
14
Midwest Heart and Vascular Spec
Overland Park, Kansas, United States, 66211
Actively Recruiting
15
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
16
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
17
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
18
Brigham and Womens Hosp Harvard Med School
Boston, Massachusetts, United States, 02115
Actively Recruiting
19
Brigham and Womens Hosp Harvard Med School
Boston, Massachusetts, United States, 02115
Actively Recruiting
20
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
21
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
22
AA Medical Research Center
Flint, Michigan, United States, 48504
Actively Recruiting
23
William Beaumont Hospital
Royal Oak, Michigan, United States, 48073-4192
Actively Recruiting
24
Minneapolis Heart Institute
Minneapolis, Minnesota, United States, 55407
Withdrawn
25
University Of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
26
Overlook Medical Center
Summit, New Jersey, United States, 07901
Actively Recruiting
27
Capital Cardiology Associates
Albany, New York, United States, 12211
Actively Recruiting
28
New York Presbyterian Hospital
New York, New York, United States, 10021
Active, Not Recruiting
29
Icahn School of Med at Mt Sinai
New York, New York, United States, 10029
Actively Recruiting
30
Strong Memorial Hospital
Rochester, New York, United States, 14642
Actively Recruiting
31
Wake Forest University Baptist Medical Center
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
32
Lindner Ctr At The Christ Hosp
Cincinnati, Ohio, United States, 45219
Actively Recruiting
33
Ohio State University
Columbus, Ohio, United States, 43210
Withdrawn
34
Perelman School of Medicine
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
35
Orion Medical
Houston, Texas, United States, 77034
Actively Recruiting
36
Virginia Heart
Falls Church, Virginia, United States, 22042
Actively Recruiting
37
Carient Heart and Vascular
Manassas, Virginia, United States, 20109
Actively Recruiting
38
Novartis Investigative Site
Innsbruck, Tyrol, Austria, 6020
Actively Recruiting
39
Novartis Investigative Site
Linz, Austria, 4021
Withdrawn
40
Novartis Investigative Site
Vienna, Austria, 1100
Actively Recruiting
41
Novartis Investigative Site
Vienna, Austria, 1190
Actively Recruiting
42
Novartis Investigative Site
Vienna, Austria, A 1090
Actively Recruiting
43
Novartis Investigative Site
Genk, Limburg, Belgium, 3600
Actively Recruiting
44
Novartis Investigative Site
Yvoir, Namur, Belgium, 5530
Actively Recruiting
45
Novartis Investigative Site
Aalst, Oost Vlaanderen, Belgium, 9300
Actively Recruiting
46
Novartis Investigative Site
Kortrijk, West-Vlaanderen, Belgium, 8500
Actively Recruiting
47
Novartis Investigative Site
Roeselare, West-Vlaanderen, Belgium, 8800
Actively Recruiting
48
Novartis Investigative Site
Cambridge, Ontario, Canada, N1R 6V6
Actively Recruiting
49
Novartis Investigative Site
North York, Ontario, Canada, M6B 3H7
Actively Recruiting
50
Novartis Investigative Site
Ottawa, Ontario, Canada, K1Y 4W7
Actively Recruiting
51
Novartis Investigative Site
Montreal, Quebec, Canada, H1T 1C8
Actively Recruiting
52
Novartis Investigative Site
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
53
Novartis Investigative Site
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
54
Novartis Investigative Site
Québec, Quebec, Canada, G1V 4G5
Actively Recruiting
55
Novartis Investigative Site
Hradec Králové, Czechia, 500 02
Actively Recruiting
56
Novartis Investigative Site
Jaroměř, Czechia, 551 01
Actively Recruiting
57
Novartis Investigative Site
Prague, Czechia, 128 08
Actively Recruiting
58
Novartis Investigative Site
Prague, Czechia, 14021
Actively Recruiting
59
Novartis Investigative Site
Prague, Czechia, 150 06
Actively Recruiting
60
Novartis Investigative Site
Esbjerg, Denmark, 6700
Actively Recruiting
61
Novartis Investigative Site
Hvidovre, Denmark, 2650
Actively Recruiting
62
Novartis Investigative Site
Roskilde, Denmark, 4000
Actively Recruiting
63
Novartis Investigative Site
Viborg, Denmark, 8800
Actively Recruiting
64
Novartis Investigative Site
Paris, France, 75012
Actively Recruiting
65
Novartis Investigative Site
Paris, France, 75013
Actively Recruiting
66
Novartis Investigative Site
Paris, France, 75015
Actively Recruiting
67
Novartis Investigative Site
Pessac, France, 33604
Actively Recruiting
68
Novartis Investigative Site
Poitiers, France, 86021
Actively Recruiting
69
Novartis Investigative Site
Rennes, France, 35033
Actively Recruiting
70
Novartis Investigative Site
Frankfurt am Main, Hesse, Germany, 60594
Actively Recruiting
71
Novartis Investigative Site
Kaiserslautern, Rhineland-Palatinate, Germany, 67655
Actively Recruiting
72
Novartis Investigative Site
Dresden, Saxony, Germany, 01099
Actively Recruiting
73
Novartis Investigative Site
Leipzig, Saxony, Germany, 04289
Actively Recruiting
74
Novartis Investigative Site
Ahaus, Germany, 48683
Actively Recruiting
75
Novartis Investigative Site
Berlin, Germany, 13353
Actively Recruiting
76
Novartis Investigative Site
Bonn, Germany, 53105
Actively Recruiting
77
Novartis Investigative Site
Essen, Germany, 45147
Actively Recruiting
78
Novartis Investigative Site
Hamburg, Germany, 20246
Actively Recruiting
79
Novartis Investigative Site
Hamburg, Germany, 22763
Actively Recruiting
80
Novartis Investigative Site
Lüneburg, Germany, 21339
Withdrawn
81
Novartis Investigative Site
Mannheim, Germany, 68165
Actively Recruiting
82
Novartis Investigative Site
München, Germany, 80636
Actively Recruiting
83
Novartis Investigative Site
Münster, Germany, 48149
Actively Recruiting
84
Novartis Investigative Site
Oldenburg, Germany, 26133
Actively Recruiting
85
Novartis Investigative Site
Beersheba, Israel, 8457108
Actively Recruiting
86
Novartis Investigative Site
Haifa, Israel, 3104802
Actively Recruiting
87
Novartis Investigative Site
Haifa, Israel, 3109601
Actively Recruiting
88
Novartis Investigative Site
Jerusalem, Israel, 9103102
Actively Recruiting
89
Novartis Investigative Site
Jerusalem, Israel, 9112001
Actively Recruiting
90
Novartis Investigative Site
Nahariya, Israel, 2210001
Actively Recruiting
91
Novartis Investigative Site
Petah Tikva, Israel, 4941492
Actively Recruiting
92
Novartis Investigative Site
Ramat Gan, Israel, 5265601
Actively Recruiting
93
Novartis Investigative Site
Tel Aviv, Israel, 6423906
Actively Recruiting
94
Novartis Investigative Site
Ancona, AN, Italy, 60126
Actively Recruiting
95
Novartis Investigative Site
Bergamo, BG, Italy, 24127
Actively Recruiting
96
Novartis Investigative Site
Bologna, BO, Italy, 40138
Withdrawn
97
Novartis Investigative Site
Brescia, BS, Italy, 25123
Actively Recruiting
98
Novartis Investigative Site
Caserta, CE, Italy, 81100
Actively Recruiting
99
Novartis Investigative Site
Cona, FE, Italy, 44124
Actively Recruiting
100
Novartis Investigative Site
Pozzilli, IS, Italy, 86077
Actively Recruiting
101
Novartis Investigative Site
Milan, MI, Italy, 20138
Actively Recruiting
102
Novartis Investigative Site
Milan, MI, Italy, 20157
Actively Recruiting
103
Novartis Investigative Site
Milan, MI, Italy, 20162
Actively Recruiting
104
Novartis Investigative Site
Padova, PD, Italy, 35128
Actively Recruiting
105
Novartis Investigative Site
Pordenone, PN, Italy, 33170
Actively Recruiting
106
Novartis Investigative Site
Amsterdam, North Holland, Netherlands, 1090 HM
Actively Recruiting
107
Novartis Investigative Site
Amsterdam, North Holland, Netherlands, 1105 AZ
Actively Recruiting
108
Novartis Investigative Site
Rotterdam, South Holland, Netherlands, 3015 GD
Actively Recruiting
109
Novartis Investigative Site
Rotterdam, South Holland, Netherlands, 3079 DZ
Actively Recruiting
110
Novartis Investigative Site
Nieuwegein, Utrecht, Netherlands, 3435 CM
Actively Recruiting
111
Novartis Investigative Site
Alcabideche, Portugal, 2755-009
Actively Recruiting
112
Novartis Investigative Site
Braga, Portugal, 4710243
Actively Recruiting
113
Novartis Investigative Site
Coimbra, Portugal, 3004-561
Actively Recruiting
114
Novartis Investigative Site
Vila Nova de Gaia, Portugal, 4434 502
Actively Recruiting
115
Novartis Investigative Site
Cáceres, Extremadura, Spain, 10003
Actively Recruiting
116
Novartis Investigative Site
Córdoba, Spain, 14004
Actively Recruiting
117
Novartis Investigative Site
Madrid, Spain, 28034
Actively Recruiting
118
Novartis Investigative Site
Madrid, Spain, 28040
Withdrawn
119
Novartis Investigative Site
Madrid, Spain, 28041
Actively Recruiting
120
Novartis Investigative Site
Madrid, Spain, 28046
Actively Recruiting
121
Novartis Investigative Site
Salamanca, Spain, 37007
Actively Recruiting
122
Novartis Investigative Site
Valencia, Spain, 46010
Actively Recruiting
123
Novartis Investigative Site
Basel, Switzerland, 4031
Actively Recruiting
124
Novartis Investigative Site
Geneva, Switzerland, 1211
Actively Recruiting
125
Novartis Investigative Site
Lausanne, Switzerland, 1011
Actively Recruiting
126
Novartis Investigative Site
Lugano, Switzerland, 6900
Actively Recruiting
127
Novartis Investigative Site
Zurich, Switzerland, 8091
Actively Recruiting
128
Novartis Investigative Site
Reading, Berkshire, United Kingdom, RG1 5AN
Actively Recruiting
129
Novartis Investigative Site
Portadown, Nothern Ireland, United Kingdom, BT63 5QQ
Actively Recruiting
130
Novartis Investigative Site
Edinburgh, United Kingdom, ED16 4SA
Actively Recruiting
131
Novartis Investigative Site
Leicester, United Kingdom, LE3 9QP
Actively Recruiting
132
Novartis Investigative Site
Liverpool, United Kingdom, L14 3PE
Actively Recruiting
133
Novartis Investigative Site
London, United Kingdom, EC1A 7BE
Actively Recruiting
134
Novartis Investigative Site
London, United Kingdom, SE1 7EH
Actively Recruiting
135
Novartis Investigative Site
Londonderry, United Kingdom, BT47 6SB
Actively Recruiting
136
Novartis Investigative Site
Manchester, United Kingdom, M23 9LT
Actively Recruiting
137
Novartis Investigative Site
Middlesbrough, United Kingdom, TS4 3BW
Actively Recruiting
138
Novartis Investigative Site
Norwich, United Kingdom, NR4 7UY
Actively Recruiting
139
Novartis Investigative Site
Tyne and Wear, United Kingdom, NE29 8NH
Actively Recruiting
Research Team
N
Novartis Pharmaceuticals
CONTACT
N
Novartis Pharmaceuticals
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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