Actively Recruiting
Randomized Multicenter Study of Taurolidine Lock Versus Standard Saline Lock for Preventing Catheter Infections in Children with Cancer
Led by Institut Curie · Updated on 2026-02-20
148
Participants Needed
5
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
This research investigates the use of a Taurolidine lock compared to a standard saline lock to prevent catheter-related infections in children and young adults undergoing cancer treatment. It is a multicenter, randomized, double-blind study aiming to evaluate the primary prevention of catheter-related endoluminal infections in pediatric oncology patients. Participants will be randomly assigned to receive either Taurolock1212 Taurolidine lock or physiological serum normal saline injected into their central catheter each time it is used. The study follows patients for up to six months after randomization, monitoring the effects of these two catheter lock solutions. During the study, patients will be followed according to their pathology and treatment protocol. Researchers will track infection rates, catheter colonizations, removals due to complications, local infections, occlusions, thrombotic issues, adverse events related to the locks, and the types of microbes found in cultures. The main outcome is the incidence of catheter-related infection measured per 1000 catheter days. Follow-up assessments will continue for an average of 56 months to gather comprehensive safety and effectiveness data.
CONDITIONS
Brief Title
Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in Paediatric Oncology
Research Team
C
Camille CORDERO, MD
M
Marie-Emmanuelle Legrier, PhD
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