Actively Recruiting
Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in Paediatric Oncology
Led by Institut Curie · Updated on 2026-02-20
148
Participants Needed
5
Research Sites
235 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Interest of a Taurolidine lock at each catheter closure in the primary prevention of catheter-related endoluminal infection in paediatric oncology. Multicentric, controlled, randomized and double-blind label study.
CONDITIONS
Official Title
Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in Paediatric Oncology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient less than or equal to 21 years of age at inclusion.
- Patient for whom a central catheter is planned to be inserted, excluding a non-tunneled femoral or cervical external catheter or a peripherally inserted central catheter (PICC line).
- Placement may be first catheter or placement following a relapse, with at least one month since previous catheter removal.
- Patient treated for cancer.
- Patient has regular follow-up at the inclusion center.
- Informed consent signed by the patient if adult or by legal representatives if minor.
- Patient has social security coverage.
- Time between catheter placement and planned first solution lock injection is less than 6 weeks.
You will not qualify if you...
- Patient with retinoblastoma.
- Allografted patient.
- Patient with life expectancy less than 6 months.
- Patient refusing to participate in the protocol.
- Patient already receiving a central venous catheter-related infection prevention lock.
- Patient with known allergy to citrate or Taurolidine.
- Patient taking drugs contraindicated with citrate or Taurolidine.
- Patient with an external femoral catheter.
- Patient with a PICC line-type peripheral venous inserted central catheter.
- Patient unable to comply with medical follow-up due to geographical, social, or psychological reasons.
- Patient under guardianship or curatorship.
AI-Screening
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Trial Site Locations
Total: 5 locations
1
Institut Curie
Paris, France, 75005
Actively Recruiting
2
Saint Louis
Paris, France, 75010
Actively Recruiting
3
Armand Trousseau
Paris, France, 75012
Actively Recruiting
4
Robert Debre
Paris, France, 75935
Actively Recruiting
5
Gustave Roussy
Villejuif, France, 94805
Actively Recruiting
Research Team
C
Camille CORDERO, MD
CONTACT
M
Marie-Emmanuelle Legrier, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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