Study of Heart Rate Variability and Traditional Weaning Tests to Improve Breathing Tube Removal in Critically Ill Patients on Mechanical Ventilation

What this Trial Is About

Researchers are studying patients who need help breathing with mechanical ventilators to improve the timing of safely removing this support. The study focuses on combining heart rate variability HRV measurements with traditional assessments for weaning patients off ventilators. Previous studies showed HRV differs between successful and failed extubation but were limited by small samples and single HRV indicators, so this study aims to develop a more objective and sensitive model using multiple HRV parameters alongside standard measures. Participants will be observed using the BEATINFO ECG Sensor device to analyze changes in HRV during key phases the Spontaneous Breathing Trial SBT, extubation, and after extubation. This observational study captures various HRV time and frequency domain parameters to evaluate how well they predict successful weaning from invasive mechanical ventilation. During the study, patients will be monitored for at least 72 hours after extubation to collect follow-up data. Researchers will assess ventilator-free days within 3 days as the primary outcome. Stable ECG signals are required for HRV analysis, and consent is obtained from patients or their legal representatives. The total participation duration includes monitoring before, during, and after ventilator removal to gather comprehensive physiological and clinical data for the predictive model.

Multidimensional Correlation Analysis of Heart Rate Variability and Weaning Assessment Parameters in Critically Mechanically Ventilated Patients