Study of Physical, Cognitive, and Psychological Effects in Adults With Post-Intensive Care Syndrome Across China

What this Trial Is About

Researchers are conducting a large-scale observational study across multiple centers in China to better understand Post-Intensive Care Syndrome PICS in patients who have survived critical illness and intensive care. The study aims to describe the patterns and extent of physical, cognitive, and psychological impairments that persist after hospital discharge, which are collectively known as PICS. This research addresses the growing need for detailed information given the increasing number of ICU survivors and the variability in critical care practices across China. Participants in this study are ICU survivors transferred to high-dependency units HDUs in four centers. The study involves collecting extensive clinical data including demographic information, disease history, and ICU treatment details. Multiple validated assessment tools will be used to measure physical strength, mobility, cognitive function, psychological health, and quality of life. Data will be gathered within 24 hours of admission to the HDU or just before ICU discharge, and assessments include tools such as the MRC score, ICU Mobility Scale, Mini-Mental State Examination, PHQ-9, GAD-7, and others. During the study, participants will undergo thorough evaluations of their physical, cognitive, and psychological status using standardized questionnaires and functional tests. Researchers will collect and analyze information on muscle strength, mobility, mental health, sleep quality, pain severity, and family caregiver anxiety and depression. The primary outcomes focus on the incidence and comorbidity patterns of PICS, while also exploring functional status, quality of life, and risk factors. The study will follow participants from admission to the HDU, with data collection spanning until the study completion in 2027, providing valuable insight into the impact of PICS on survivors of critical illness.

Multidimensional Dysfunction in Patients With Post-Intensive Care Syndrome in China