Actively Recruiting
Multidimensional Omics Analysis in Malignant Pleural Mesothelioma
Led by Azienda USL Reggio Emilia - IRCCS · Updated on 2026-05-01
300
Participants Needed
4
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Malignant pleural mesothelioma (MPM) is a rare and incurable cancer. Most patients are diagnosed with unresectable disease for which treatment options are limited. The lack of prognostic biomarkers further complicates the decision-making. Recently, the introduction of immune checkpoint inhibitors (ICIs) has marked a shift but has failed to produce significant benefits for a large proportion of patients. Maximizing the efficiency of ICIs and developing new protocols to improve drug efficacy is the best possible strategy for improving the life expectancy and quality of life of patients with MPM. This study aims to characterize the organization of the immune system infiltrating mesothelioma and the dynamics of its interaction with the tumor. The rationale is that deciphering this complexity will help improve our understanding of the mechanisms underlying this disease and provide a new tool to optimize the use of ICIs in these patients.
CONDITIONS
Official Title
Multidimensional Omics Analysis in Malignant Pleural Mesothelioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to provide informed consent for the study
- Age greater than 18 years
- Histologically confirmed diagnosis of malignant pleural mesothelioma
- Availability of biological material for analysis
- Clinical eligibility for the hyperthermic intrathoracic chemotherapy (HITHOC) protocol (for C3 cohort only)
You will not qualify if you...
- Presence of active current infection
- Diagnosis of autoimmune disease
- Women of childbearing age who cannot exclude pregnancy
AI-Screening
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Trial Site Locations
Total: 4 locations
1
Azienda Ospedaliera Universitaria Policlinico Rodolico San Marco di Catania
Catania, Italy
Actively Recruiting
2
Azienda Ospedaliera Universitaria Luigi Vanvitelli, Napoli
Naples, Italy
Actively Recruiting
3
Azienda USL IRCCS di Reggio Emilia
Reggio Emilia, Italy
Actively Recruiting
4
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, Italy
Actively Recruiting
Research Team
A
Alessia Ciarrocchi, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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