Actively Recruiting
Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia
Led by Children's Hospital of Philadelphia · Updated on 2025-07-20
130
Participants Needed
1
Research Sites
295 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital of Philadelphia
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Bronchopulmonary Dysplasia (BPD), or chronic lung disease of prematurity, is the most consequential complication of preterm birth and is strong predictor of childhood pulmonary and neurodevelopmental disability, particularly in infants diagnosed with grade 3 BPD (ventilator dependence at 36 weeks' postmenstrual age), the most severe disease form. This study aims to (1) generate the first empirically defined phenotype classification system for grade 3 BPD developed using a rich array of objective and quantitative cardiopulmonary diagnostic, clinical, and biological data; and (2) define the association between phenotype subgroups and neurodevelopmental and respiratory outcomes through 2 years' corrected age.
CONDITIONS
Official Title
Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infant born before 32 weeks gestational age
- Postmenstrual age between 36 and 65 weeks at enrollment
- Receiving invasive ventilation at enrollment
- Diagnosed with grade 3 BPD or grade 2 BPD needing chronic invasive ventilation
- Parental or guardian informed consent provided
You will not qualify if you...
- Contraindication to one or more study diagnostic procedures
- Family unable or unlikely to commit to 2-year follow-up
- Infant unlikely to survive the 6-8 week diagnostic period
- Parental or guardian consent not provided
- Presence of aneuploidy or severe congenital abnormality not representative of BPD
- Parent or guardian unable or unlikely to complete study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
E
Erik Jensen, MD, MSCE
CONTACT
K
Krithika Lingappan, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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