Actively Recruiting
Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)
Led by Florida Institute for Human and Machine Cognition · Updated on 2026-04-22
250
Participants Needed
2
Research Sites
239 weeks
Total Duration
On this page
Sponsors
F
Florida Institute for Human and Machine Cognition
Lead Sponsor
U
University of Florida
Collaborating Sponsor
AI-Summary
What this Trial Is About
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.
CONDITIONS
Official Title
Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 60 or above
- Free of chronic disease
- No structured exercise program (2 or more bouts per week) within previous 12 months
- Cognitively capable of providing informed consent
You will not qualify if you...
- Neuromuscular or musculoskeletal disorder limiting ability to exercise or undergo testing
- Cardiopulmonary disorders or reduced breathing capacity
- Metabolic diseases including liver disease markers (ALT > 52 U/l) or type 2 diabetes (HbA1C 65 6.5, fasting blood glucose 65 126 mg/dl)
- Diseases influencing exercise response (e.g., chronic kidney disease, dementia, recent cancer, cerebrovascular disease)
- History of chemotherapy within 5 years
- Current infectious disease
- Life expectancy less than 1 year
- Use of insulin sensitizing or blood glucose lowering agents such as metformin
- High dose statin use (equivalent to 60 mg/d simvastatin or more)
- Lidocaine allergy
- Regular tobacco use or vaping
- Excessive alcohol consumption (3 drinks/day or 7 drinks/week for females; 4 drinks/day or 14 drinks/week for males)
- Body mass index less than 35.0 kg/m2
- Unable to commit to approximately 6 months to complete the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Florida Institute for Human and Machine Cognition
Pensacola, Florida, United States, 32502
Actively Recruiting
2
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
Research Team
C
Craig Tuggle
CONTACT
M
Marcas Bamman, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
2
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