Actively Recruiting
A Multifocal tDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early Dementia
Led by University of Campania Luigi Vanvitelli · Updated on 2026-04-22
50
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if an integrated protocol using multifocal non invasive brain stimulation and brain recording combined with cognitive training is effective in treating cognitive and affective symptomatology in patients with mild cognitive impairment and early stages of dementia. The main questions it aims to answer are: * Does multifocal non-invasive brain stimulation reduce cognitive and affective symptoms in patients with mild cognitive impairment and early stages of dementia? * Do some specific factors, such as education and cognitive reserve, affect the extent of the possible outcomes achievable from the intervention? * Do electrophysiological measures contribute identifying responders and non-responders to the treatment? Researchers will compare real non-invasive brain stimulation to a placebo stimulation (reproducing the same feeling of stimulation without actually stimulating the brain) combined with cognitive rehabilitation on general cognition measures and depression symptoms. Participants will * Undergo two treatment cycles (real stimulation or placebo over frontal and temporal ares of the left hemisphere) combined with cognitive training twice a week for two months. * Complete neuropsychological evaluations before the first rehabilitation cycle and at the end of each rehabilitation cycle. Caregivers will provide information on functional daily living activities for their relatives.
CONDITIONS
Official Title
A Multifocal tDCS-EEG Protocol for Improving Symptoms of Mild Cognitive Impairment and Early Dementia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 55 and 85 years
- Diagnosis of mild neurocognitive disorder or mild major neurocognitive disorder according to DSM-5, with Clinical Dementia Rating Scale of 0.5 or 1
- Right-handedness
You will not qualify if you...
- History of acute brain events such as stroke, traumatic brain injury, or brain surgery
- Psychiatric disorders including schizophrenia, psychosis, bipolar disorder, or use of psychotropic drugs
- Diagnosis of moderate or severe major neurocognitive disorder with Clinical Dementia Rating Scale score of 2 or higher
- Conditions interfering with brain stimulation or recordings such as metallic brain implants, cochlear implants, pacemakers, or epilepsy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Psychology, University of Campania "Luigi Vanvitelli"
Caserta, Italy, Italy, 81100
Actively Recruiting
Research Team
F
Francesco Panico, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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